Contrary to the accepted hypothesis positing downregulation of low-density lipoprotein receptor (LDLR) in humans, expression of the human APOE4 isoform combined with increased LDLR was harmful in genetically modified mice when red a high-fat Western diet, predicting important interactions between genotype/phenotype and exposure.

Annual scientific retreat: predisposing factors in the development of ... by Environmental Health Perspectives

Most members of both groups initially had near-normal scores for low-density lipoprotein (LDL) cholesterol, the harmful kind.

Tackling stroke and heart risks by Science News

At the end of the study, the walnut group had significantly lower total cholesterol as well as lower low-density lipoprotein levels (LDL, the bad cholesterol) as compared to the regular Mediterranean diet.

Walnuts-RX for high cholesterol by Running & FitNews

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