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lyase |
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lyase [′lī‚ās] (biochemistry) An enzyme that catalyzes the nonhydrolytic cleavage of its substrate with the formation of a double bond; examples are decarboxylases. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The research program includes the pleuromutilins, a novel class of antibiotics, and two target-based projects, isocitrate lyase (Icl) and InhA. Boyd and Chakrabarty (70) studied alginate lyase production in P aeruginosa to determine whether increased expression of this enzyme affected the size of the alginate molecules (and therefore adhesion of the organisms). The second enzyme of this pathway for which the structure has been solved to high resolution is chorismate lyase from Eschierichia coli. |
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