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(chemical engineering)
Rapid freezing of a material, especially biological specimens for preservation, at a very low temperature followed by rapid dehydration by sublimation in a high vacuum.



freeze-drying, the drying of biological objects in a frozen state under vacuum, the water being removed by sublimation of the ice (that is, conversion to steam, bypassing the liquid phase).

Lyophilization makes it possible to obtain dry tissues, medical preparations, and food products without a loss of structural integrity and biological activity. Most proteins are not denatured by the process and can be stored for a long time afterward under moderate cold (about 0°C). Freeze-dried tissues and preparations regain their initial properties when wetted. The process is used when there is a need for the long-term storage and preservation of various products of biological origin; to obtain dry donor plasma and dry sera and vaccines; for organ and tissue transplants; and in the pharmaceuticals and food industries. In the life-support systems of spaceships, it may be used as a means of regenerating water from moisture-containing materials.


Primenenie zamorazhivaniia-vysushivaniia ν biologii. Edited by R. Harris. Moscow, 1956. (Translated from English.)
References in periodicals archive ?
Studies confirm that lyophilization is much simpler, effective and convenient for preservation of fungal cultures in the laboratory at large scale as compared to conventional freeze-drying methods [23, 24, 25].
The global lyophilization equipment market is segmented by technology, scale of operation, application, accessories, and region.
She wants to build out the centre with this lyophilization method to service all of Ontario, and possibly Canada.
The process of lyophilization, or freeze drying, is used to dehydrate samples in order to preserve them for transportation or future study or to prepare them for analysis.
The typical methodology for producing powders from aqueous solution is lyophilization (or freeze drying), which cannot normally accept acetonitrile.
The successful inspection was conducted primarily with regard to two additional products manufactured on behalf of clients in the DRAXIS Pharma sterile lyophilization (freeze-drying) production facility.
Disadvantages are the necessary reconstitution and the alteration of analyte concentrations during lyophilization.
The report"Lyophilization Equipment Market by Type (Tray-style, Manifold, Shell (Rotary), Mobile), Application (Food, Pharmaceutical, Biotechnology, Diagnostics), Scale of Operations (Industrial, Pilot, Lab), Accessories & by Region - Global Trends & Forecast to 2020", published by MarketsandMarkets, The Lyophilization Equipment Market is projected to reach USD 2.
This collaboration with Affinity Life Sciences provides us with the capabilities needed for lyophilization, also known as freeze-drying, biomarker assay and quality control development and production.
Lyophilization technology continues to advance as academicians, industry scientists and manufacturers of lyophilization equipment and analytical instrumentation discover and develop new approaches and methodologies.
Union City, CA), a medical products company manufacturing point-of-care blood analysis systems, announced that it has completed an agreement to license a portion of its patent portfolio covering lyophilization technology to bioMerieux SA.