lysin


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Lysin

A term used to describe substances that will disrupt a cell, with the release of some of its constituents. Unless the damage is minor, this action leads to the death of the cell. Lysins vary in the range of host species whose cells they will attack and in their requirements for accessory factors for lysis; the immune lysins are strictest in their requirements. Erythrocytes are lysed by a wide variety of chemicals, including water and hypertonic salt solutions, which displace the osmotic pressure from that of isotonicity. They are also susceptible to surface-active substances, such as saponin. Many bacteria, such as the staphylococcus and the streptococcus, elaborate one or more hemolysins that will lyse erythrocytes from certain, although not all, species of animals. See Lytic reaction

lysin

[′līs·ən]
(immunology)
A substance, particularly antibodies, capable of lysing a cell.
References in periodicals archive ?
10), (14) They recently solved the X-ray crystal structure of PlyC, the most powerful lysin known, providing clues to its superior potency.
NK lysin is produced by host lymphocytes that are activated by parasites during coccidiosis infection in the gut.
More recently, PlyG lysin, purified from phage-[gamma] (specific to B.
This is a very clever exploitation" of lysin, says biowarfare researcher Stephen Morse of Columbia University.
Fujifilm Diosynth Biotechnologies and ContraFect Corporation announced today that they have signed a contract to support the process development and cGMP manufacture of CF-301, ContraFect's Staphylococcal-specific bacteriophage lysin
A biotechnology company focused on the development and commercialization of novel phage and lysin antibacterial products and solutions, Phagelux, Inc.
The assets purchased include intellectual property for multiple lysins and for the rapid development of lysin solutions.
26 October 2011 - Fujifilm Diosynth Biotechnologies, a subsidiary of Fujifilm Holdings Corporation (TYO:4901) and ContraFect Corp said they had signed an agreement for the development and manufacture of CF-301, ContraFect's Staphylococcal-specific bacteriophage lysin.
7 (DQ785757) Lysin precursor, gene intron 4 Halions rufescens HmRS54D (AF076822.
Palo Alto, CA) has patented incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein.
Automation is done strictly with the use of pipetting to add blood to the tube, lysin the blood, and wash and set up the PCR reactions.