macrolide


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macrolide

[′mak·rə‚līd]
(organic chemistry)
A large ring molecule with many functional groups bonded to it.
References in periodicals archive ?
The macrolide antibiotics can inhibit the cytochrome P450 microsomal enzyme CA4.
Although we anticipate that solithromycin will become available only in the United States and its prescriptions will be reserved primarily for patients failing marketed macrolides, the wide use of macrolides in inpatients and outpatients and solithromycin's availability in both oral and IV formulations will enable the drug to garner combined sales of nearly $100 million in 2021," said Decision Resources Therapeutic Area Director Irene Koulinska, M.
genitalium-positive patients, 200 specimens underwent complete analysis for the gyrA and parC genes, specimens from 221 patients were investigated for macrolide resistance, and specimens from 168 patients were examined for 23S rRNA, gyr A, and parC genes.
A total of 656 patients were assigned to receive beta-lactam monotherapy, 739 to receive beta-lactam plus macrolide combination therapy, and 888 to receive fluoroquinolone monotherapy.
Clinical cure rate at day 14 was 32 out of 36 patients given any macrolide, and 11 out of 12 given macrolide monotherapy.
Non antimicrobial activity: Apart from its conventional antibacterial action macrolide antibiotics are known to have anti-inflammatory (6), immunomodulator acitivity (7 & 8) and antioxidant properties (9) and Erythromycin has been used clinically for its stimulatory effect on gastrointestinal motility.
Those who were given the macrolide had a nearly 50 percent higher risk of cardiovascular death, primarily from heart attack, than those given other types of antibiotic.
We chose to determine macrolide resistance by comparing resistance rates only in the colonized patients (66 on azithromycin and 172 on placebo), not the whole group--the majority of whom were not colonized at all.
On physical examination, only respiratory rate (RR) was significantly different: more patients on macrolide (64%) had a RR > 30 ipm than patients on ceftriaxone alone (36%) [p = 0.
Malhotra-Kumar and associates used subjects' oral commensal streptococcal flora, which harbors the same macrolide resistance genes as pathogenic strep organisms do, as a model to study the effects of azithromycin and clarithromycin exposure on antibiotic resistance.
7) more likely to have been recently treated with gatifloxacin than with a macrolide antibiotic, said Laura Y.