crystals as magnetic micro-rotors: key for high-sensitivity diagnosis.
2 mmol/L) Acidosis (plasma bicarbonate <15 mmol/L or serum lactate >5 mmol/L) Hepatic transaminases >3 times normal Renal impairment (serum creatinine >265 [micro]mol/L or rapidly rising creatinine or urine output <400 mL/day in an adult) Haemoglobin <5 g/L Parasitaemia [greater than or equal to] 5% [greater than or equal to] 5% neutrophils contain malaria pigment
Presence of schizonts of P.
Association of intraleukocytic Plasmodium falciparum malaria pigment
with disease severity, clinical manifestations, and prognosis in severe malaria.
Presence of falciparum schizonts and/or malaria pigment in 5% or more of neutrophils on a blood film are considered to be poor prognostic signs (12,77,78).
Intraleucocytic malaria pigment and prognosis in severe malaria.
Sometimes parasites cannot be found in peripheral blood smear from patients with malaria, but malaria pigment
may be seen in circulating phagocytic leucocytes.
The paper entitled "Quinoline Binding Site on Malaria Pigment
Crystal: A Rational Pathway for Anti-Malaria Drug Design" is also available through http://pubs.
vivax has been inconsistently associated with the presence of malaria pigment
in the placenta, but not associated with placental pathologic changes (14,31).
Monocytes and neutrophils may ingest birefringent depolarizing malaria pigment
that can be detected by the instrument.