matrix metalloproteinase


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Related to matrix metalloproteinase: matrix metalloproteinase 12, matrix metalloproteinase 2, matrix metalloproteinase 9

matrix metalloproteinase

[¦mā·triks mə‚tal·ō′prō·tē·ə‚nās]
(biochemistry)
Any member of a family of at least 19 structurally related zinc-dependent neutral endopeptidases collectively capable of degrading essentially all components of extracellular matrix.
References in periodicals archive ?
Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window.
Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates.
Shim KN, Jung SA, Joo YH, Yoo K: Clinical significance of tisue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer.
Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells: activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties.
28) Matrix metalloproteinases and ADAMTSs are two major protease families that play role in breakdown of ECM.
Resveratrol inhibits TNF-alpha-induced proliferation and matrix metalloproteinase expression in human vascular smooth muscle cells.
During the cardiac remodeling process, ordinarily quiescent fibroblast transforms into a proliferative and invasive myofibroblast phenotype and initiates structural changes to the cardiac interstitium, which is regulated in part by matrix metalloproteinases (MMPs) (Porter et al.
2010 JVIR Editor's Award for Outstanding Laboratory Investigation: "Hypoxia-induced Phenotypic Switch of Fibroblasts to Myofibroblasts Through a Matrix Metalloproteinase 2/tissue Inhibitor of Metalloproteinase-mediated Pathway: Implications for Venous Neointimal Hyperplasia in Hemodialysis Access," S.
The expression of matrix metalloproteinases 1, 2, and 9 was not significantly changed, but an increased level of tissue inhibitor of matrix metalloproteinase 1 mRNA was observed without modification of tissue inhibitor of matrix metalloproteinase 2 mRNA.
Increased expression of matrix metalloproteinase and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.
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