As far as good outcome is concerned, combined obstetric and paediatric care can lead to prevention and reduced severity of meconium aspiration
syndrome with low complication rate and decrease mortality.
The study population was similar to ours and 66% were delivered by caesarean section mostly due to foetal distress and meconium aspiration
, but surprisingly there were no neonatal sequale.
Given the incidence of meconium aspiration
syndrome, "from a national perinatal database, we think we would require about 480 babies to study the difference," said Dr.
Causes N (%) Pneumonia/Sepsis 3(30%) Hyaline Membrane Disease 2(20%) Meconium Aspiration
2(20%) Congenital diaphragmatic hernia 1(10%) Spontaneous 2(20%) Table 2: Incidence of Pneumothoraces.
After exclusion of infants with meconium aspiration
, the risk estimates increased slightly, the researchers said.
The meconium aspiration
causes brain damage so we just have to take it day by day to see if there's any effects of brain damage but at the moment the doctors are pleased with his progress.
Results: The rate of meconium aspiration
syndrome exceeded national averages prior to the change in the source of the community water and then decreased to within national averages.
The prevention of meconium aspiration
in labor using amnioinfusion.
Discovery is currently conducting a Phase 2 clinical trial for Acute Respiratory Distress Syndrome in adults, Phase 3 and Phase 2 clinical trials for Meconium Aspiration
Syndrome in full-term infants.
Discovery's Surfactant Replacement Therapy is also in a Phase 2 clinical trial for Acute Respiratory Distress Syndrome in adults, a Phase 3 and a Phase 2 clinical trial for Meconium Aspiration
Syndrome in full-term infants, and a Phase 1b clinical trial for asthma.
The primary outcomes measured were neonatal mortality in the absence of a major congenital malformation or moderate-to-severe morbidity (admission of an infant to the neonatal intensive care unit with cord-blood metabolic acidosis, neonatal seizures, hypotonia lasting >4 hours, mechanical ventilation >15 minutes, use of inotropic support, renal failure, or meconium aspiration
A comparison group of 54 infants had only three cases of complications: respiratory distress, meconium aspiration
, and jaundice.