megaloblast

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megaloblast

[′meg·ə·lō‚blast]
(pathology)
A large nucleated erythroblast appearing in bone marrow in vitamin B12 or folic acid deficiency.
References in periodicals archive ?
KEY WORDS: Aplastic Anemia, Bone Marrow Biopsy, Megaloblastic Anemia, Pancytopenia.
In conclusion, we suggest that nitric oxide is associated with the serum level of vitamin B12 in patients with megaloblastic anemia.
Sideroblastic anaemia: This occurs soon after the megaloblastic change and appears to be related to either pyridoxine deficiency or an intracellular enzyme defect.
In megaloblastic anemia, patients has low RBCs count and RBC are larger in size ( >100fl).
Megaloblastic anemia and vitamin B12 deficit were reported in 1 and 5 patients, respectively (36-38).
A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin [B.
B Vitamins: A deficiency of B6 has been shown to depress immunity; lack of adequate vitamin B12 and folate can cause megaloblastic anemia that depresses white blood cell counts; and thiamin, riboflavin and pantothenic acid each play a supporting role in optimal immune response.
Megaloblastic anaemia due to vitamin B12 deficiency was diagnosed through a combination of clinical and laboratory findings, including clinical presentation, increased mean corpuscular volume (macrocytosis), hypersegmentation of neutrophils, and low vitamin B12 levels.
2 Impaired platelet production occurs in BM failure megaloblastic anaemia leukaemia myeloma myelofibrosis solid tumor infiltration aplastic anaemia and paroxysmal nocturnal haemoglobinuria (PNH).
Different types of anemia, including iron deficiency anemia (IDA), anemia of chronic disease (ACD), the combination of IDA and ACD (COMBI) anemia, megaloblastic anemia, and hemolytic anemia, have been seen in patients with RA.
Key features distinguishing the main differential diagnoses of VACTERL association Syndrome Features distinct from VA Fanconi anaemia Haematologic abnormalities, especially megaloblastic anaemia Pigmentation abnormalities, especially hyperpigmentation or Cafe au lait spots Propensity to develop malignancies Alagile syndrome Biliary duct abnormality Eye anomalies Facial abnormality Charge syndrome Choanal atresia Colobomata Growth impairment Ear anomalies Feingold syndrome Digital phalangeal abnormalities Microcepahly Cognitive impairment Typical facial appearance Oculo-auriculo- Microtia vertebral syndrome Hemifacial microsomia Neurocognitive impairment Deletion 22q11.
Chronic occupational exposure to nitrous oxide may cause depression of vitamin B12 activity11 and altered DNA synthe- sis in the bone marrow and mild megaloblastic changes.