megaloblast

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megaloblast

[′meg·ə·lō‚blast]
(pathology)
A large nucleated erythroblast appearing in bone marrow in vitamin B12 or folic acid deficiency.
References in periodicals archive ?
A syndrome of methylmalonic aciduria, homocysteine, megaloblastic anemia and neurologic abnormalities in a vitamin B12 deficient breast-fed infant of a strict vegetarian.
Diphyllobothrium pacificum infection is seldom associated with megaloblastic anemia.
For example, of great importance with the identification of megaloblastic change is the exclusion of other associated causes such as vitamin B12 and folate deficiencies, myelodysplastic syndrome, certain medications, and alcohol.
Folate deficiency exacerbates the anaemic state as it can lead to both megaloblastic and folate deficiency anaemia [11].
Table 1: Etiological Profile of Pancytopenia Diagnoses Adults Children Total number of % (>18 years) (1-18 years) patients (n = 59) (n = 21) (n = 80) Megaloblastic 30 3 33 41.
Fifty-two contributed chapters begin with coverage of stem cells and haemopoiesis, erthropoiesis, iron metabolism and disorders of haem synthesis, iron overload, and megaloblastic anaemia; the collection concludes with primary immune thrombocytopenia, haemtological aspects of system disease, and of tropical diseases, and neonatal haematology.
Patients suspected of megaloblastic anaemia on account of a raised mean corpuscular volume (MCV>110fl), were confirmed mostly by bone marrow examination or serum vitamin B12/folic acid assay in some of the cases.
METHODS: Patients were diagnosed on the basis of low serum B12 or megaloblastic bone marrow or both.
Disease Number of cases Neoplastic disease: 70/406 cases Known myeloid leukaemia 50 Other neoplasias (Nonhaematopoietic neoplasms) 20 Cytopenia: 257/406 cases Idiopathic thrombocytopenia purpura 86 Megaloblastic anaemia 74 Others 97 Infectious disease: 79/406 cases Table 4.
Also we can infer that in chronic inflammatory conditions or infections, megaloblastic anaemia can be seen.
Chen et al have reported the occurrence of megaloblastic anemia in a young woman with chronic autoimmune thyroiditis, who has presented with iron deficiency anemia that has been diagnosed initially (15).