Findings from the present case study suggest that vitamin B12 deficiency should be considered in the aetiological diagnosis of neurological symptoms in infants, especially in the presence of megaloblastic anaemia
and developmental delay.
Anisocytosis is found to be much higher in megaloblastic anaemia
as compared to non-megaloblastic anaemia
Patients with megaloblastic anaemia
and normal HPLC findings, showed significantly higher [HbA.
So the causation of megaloblastic anaemia
in malaria remains elusive and can be confirmed by measuring methionine synthase level in blood and peripheral blood smear in chronic asymptomatic cases where sustained NO production is evident.
There is megaloblastic anaemia
, very low serum vitamin B12 and excretion of MMA and homocysteine in the urine.
Impaired DNA synthesis secondary to cobalamin deficiency causes changes in the peripheral blood and bone marrow cells; retarded cell division results in macrocytosis, hypersegmented granulocytes and megaloblastic anaemia
The bone marrow aspiration of megaloblastic anaemia
showed numerous megaloblasts with large cells with an increased nuclear/cytoplasmic ratio, sieve-like chromatin and giant metamyelocytes (Figure B).
Other notable signs of anaemia include paleness of skin and mucous membrane Specific features are related to specific causes such as koilonychia in iron deficiency, atrophic glossitis in megaloblastic anaemia
Histopathological analysis of bone marrow trephine biopsies revealed megaloblastic anaemia
as the most common cause of pancytopenia (30%), followed by aplastic anaemia (25%) and hypersplenism (15%).
He contributed substantially to research and to the medical literature on nutritional megaloblastic anaemia
In contrast to these are the results of several studies done in India in which megaloblastic anaemia
stands out as the commonest aetiological factor.
Deficiency of folate results in megaloblastic anaemia
due to impaired synthesis of DNA with failure of normal cell division and maturation of the red blood cells.