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megaloblastic anemia

   Also found in: Dictionary/thesaurus, Medical, Acronyms, Wikipedia 0.01 sec.
megaloblastic anemia [¦meg·ə·lō¦blas·tik ə′nē·m̄e·ə]
(medicine)
Anemia characterized by the occurrence of megaloblasts in the bone marrow and blood.


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In reviewing the patient's chart, you quickly noticed the anemic blood values for hemoglobin and hematocrit, but you also noticed the red blood cell indices (MCV and MCH) suggested not the typical iron deficiency anemia (microcytosis), but a megaloblastic anemia.
Megaloblastic anemia and non-megaloblastic macrocytic anemia together form a group, called macrocytic anemia.
The cause of megaloblastic anemia is primarily a failure of DNA synthesis with preserved RNA synthesis, which result in restricted cell division of the progenitor cells.
 
 
 
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