Ltd and ioversol by Jiangsu Hengrui Medicine are placed on the second group, and iohexol produced by GUERBET LABS (a French company) and BEILU Pharmaceutical and meglumine
diatrizoate by Shanghai Xudong Haipu Pharmaceutical Co.
All castrations were performed under local anaesthesia and analgesia (2% lidocaine, [Xilocaina Ovejero, Laboratorios Ovejero, Spain] followed by a non-steroidal anti-inflammatory [Flunixin Meglumine
, Laboratorios Karizoo S.
According to local protocols, patients were treated with 20 mg/kg of intramuscular meglumine
antimoniate or with 18-38 mg/ kg of intravenous liposomal amphotericin B; at publication time, the patients were still being followed.
In a study with bobwhite quail (Colinus virginianus), a dose of flunixin meglumine
after a 24-hour dehydration period was reported to cause glomerular lesions 7 days after therapy.
The first choice treatment of CL is pentavalent antimony compounds including meglumine
antimoniate (MA) and sodium stibogluconate (SSG), which are widely prescribed despite their toxicity, high cost, difficulty in administration and emergence of resistant parasites (6-8).
GTM or meglumine
antimoniate is a synthetic anti-leishmanial drug based on pentavalent antimonial (Sbv) that have been clinically recommended as first line drug to treat the infections by L.
(Dotarem), a gadolinium-based contrast agent, is indicated to detect and visualize areas with disruption of the blood brain barrier and/or abnormal vascularity.
MSF donated 1,200 vials of the drug Meglumine
Antimoniate (Glucantime) in the last week of April.
Positive contrast radiography of urinary bladder was performed using contrast agent (diatrizoate meglumine
and diatrizoate sodium-76%) on days 30, 60 and 90 post-implantation to evaluate the healing status.
In one sample after anesthetized by rabbit between anus and penis gently cut and crura identified and the amount 5ml meglumine
compound 60% into crura were injected, quickly radiograph was obtained in lateral and ventral position was observed with injection of contrast material in the crura, erection in the penis and drainage vessels in the penis was determined by X-ray and veins were identified.
(Hexabrix 320, Guerbet, France) was used as contrast agent.
Toxicity and efficacy of the antileishmanial drug meglumine
antimoniate in the owl monkey (Aotus trivirgatus).