16) It can be divided clinically into ocular melanocytosis and oculodermal melanocytosis (Naevus of Ota), the latter referring to when the periocular skin is also affected (unilaterally), most commonly in the distribution of the first and second divisions of the trigeminal nerve.
Congenital ocular melanocytosis predisposes to uveal melanoma, as well as melanoma of the ipsilateral skin, orbit, optic nerve head and brain.
Intracranial and intraspinal meningeal melanocytosis
Why should congenital oculodermal melanocytosis
be referred to ophthalmology?
Blue nevus, also known as pigmented melanocytosis or prostatic pigmentary nevohyperplasia, is the most frequently reported pigmented lesion with 28 cases reported to date.
Blue nevus of the prostate, also called pigmented melanocytosis and prostatic pigmented nevohyperplasia, is similar to its cutaneous counterpart.
is a congenital, unilateral condition involving hyperpigmentation of the uveal tract and episclera.
Lifetime prevalence of uveal melanoma in white patients with oculo(dermal) melanocytosis.
Keratinocyte expression of transgenic hepatocyte growth factor affects melanocyte development, leading to dermal melanocytosis.
In a large clinical series, (5) 8 of 4500 patients presented with bilateral melanoma; no specific syndrome was identified other than ocular melanocytosis
for 2 patients.
Its presence is more prominently observed in darkly pigmented individuals and in certain pathologic conditions, including meningeal melanocytosis
and certain tumors (melanocytoma and melanoma).