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Related to melanomas: malignant melanoma, skin cancer


see skin cancerskin cancer,
malignant tumor of the skin. The most common types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. Rarer forms include mycosis fungoides (a type of lymphoma) and Kaposi's sarcoma.
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melanoblastoma; a malignant tumor that consists of melanin-producing cells.

Factors conducive to the development of melanomas include injury and hormonal stimulation, especially during puberty. Melanomas generally occur on the skin; less often, they appear on the retina, pia mater, nasopharynx, larynx, esophagus, and mucosa of the intestine and other organs. Melanomas usually develop at the site of pigmented or depigmented birthmarks, but they may also appear elsewhere. The process starts with a barely perceptible, painless tumor on the skin, sometimes resembling a wart, which gradually becomes dark brown or black. Occasionally, it ulcerates and bleeds. In case of injury, the tumor may enlarge quickly and become tuberous, dense at the base, and stiffer. The regional lymph nodes enlarge. The initial signs that a melanoma is developing at the site of a birthmark are the birthmark’s enlargement, an intensification or reduction in its pigmentation, and the appearance of a red rim around it. Treatment involves prompt surgical intervention, based on early diagnosis, and the use of radiotherapy and drugs to retard the growth and reproduction of the cells.



A malignant tumor composed of anaplastic melanocytes.
A benign or malignant tumor composed of melanocytes.


Pathol a malignant tumour composed of melanocytes, occurring esp in the skin, often as a result of excessive exposure to sunlight
References in periodicals archive ?
Genetic factors play a major role in familial melanoma, but a more subtle role in the common sporadic melanomas where an increased risk is present in individuals with combinations of alleles and genotypes that confer susceptibility.
Performing thorough self-skin examinations each month and visiting a dermatologist each year for a professional examination, can help catch melanoma in its early stages, dramatically increasing survival rates.
On the basis of this and other findings, the researchers calculate that the risk of melanoma rises after 15 years, especially in people who have received 250 or more doses of PUVA.
And younger patients have more melanomas on the trunk than on the sun-exposed areas of the head and neck, he added.
In mice with existing melanomas, betulinic acid stalled tumor growth.
GammaCan is the first to use IgG to treat melanoma and other cancers.
Most of the foot/ankle melanomas were diagnosed in the past decade, most likely because of the increased U.
The first attempt to deploy human monoclonal antibodies in the fight against cancer has resulted in dramatic disappearance of tumors in patients with recurrent, malignant melanoma.
Whether or not they play a role in future vaccines, he says, they could be used during diagnosis to separate malignant melanoma from so-called dysplastic nevi, moles that resemble melanomas but and benign.
More than 95,000 people will develop melanoma this year and almost 8,000 will die from the disease.
The truth is, melanoma is believed to be genetically triggered," Stepp explained.