meprobamate


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meprobamate

(məprō`bəmāt'), tranquilizing drug that acts as a depressantdepressant,
any one of various substances that diminish functional activity, usually by depressing the nervous system. Barbiturates, sedatives, alcohol, and meprobamate are all depressants. Depressants have various modes of action and effects.
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 of the central nervous systemnervous system,
network of specialized tissue that controls actions and reactions of the body and its adjustment to the environment. Virtually all members of the animal kingdom have at least a rudimentary nervous system.
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 and is commonly used in the treatment of anxietyanxiety,
anticipatory tension or vague dread persisting in the absence of a specific threat. In contrast to fear, which is a realistic reaction to actual danger, anxiety is generally related to an unconscious threat.
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 and sometimes schizophreniaschizophrenia
, group of severe mental disorders characterized by reality distortions resulting in unusual thought patterns and behaviors. Because there is often little or no logical relationship between the thoughts and feelings of a person with schizophrenia, the disorder has
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. Although meprobamate is chemically unlike barbituratesbarbiturate
, any one of a group of drugs that act as depressants on the central nervous system. High doses depress both nerve and muscle activity and inhibit oxygen consumption in the tissues. In low doses barbiturates act as sedatives, i.e.
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 and has lower toxicity, it has similar pharmacological effects, especially the ability to induce sleep and alleviate anxiety. The drug possesses some anticonvulsant properties and is used to suppress some forms of epilepsyepilepsy,
a chronic disorder of cerebral function characterized by periodic convulsive seizures. There are many conditions that have epileptic seizures. Sudden discharge of excess electrical activity, which can be either generalized (involving many areas of cells in the brain)
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. A muscle relaxant, meprobamate is also used to treat abnormal motor activity. It is marketed under the trade names Equanil and Miltown.
References in periodicals archive ?
The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat.
I realized I could no longer use benzedrine and finish my residency, so I gave it up and switched to meprobamate, an old tranquilizer from the 1950s.
Similar accidental discoveries led to the identification of amphetamine as a stimulant in the course of refining a treatment for asthma, and meprobamate as an anti-anxiety treatment in the course of testing an antibiotic.
DAWN Medical Examiner Mentions (1999) Drug Mentions diazepam (Valium) 811 diphenhydramine (Benadryl) 641 Elavil (antidepressant) 477 nortriptyline (antidepressant) 424 acetaminophen (Tylenol) 427 lidocaine (heart drug & local 384 anesthetic) Prozac 305 quinine 250 meprobamate (tranquilizer) 170 aspirin 104 Source: Drug Abuse Warning Network
Calcium-channel-blocking agent in the treatment of acute alcohol withdrawal--caroverine versus meprobamate in a randomized double-blind study.
The records reveal that Kennedy took codeine, Demerol and methadone for pain, Ritalin, a stimulant, meprobamate and librium for anxiety barbiturates for sleep, thyroid hormone, and injections of a blood derivative, gamma globulin, presumably to combat infections.
CLASS C: Temazepam, Diazapan, Tranquilisers, Pipradrol, Dextro- propoxyphene, Anabolic steroids, Diethylpropion, Meprobamate, Benzodiazepine, Rohypnol.
In May, the California Horse Racing Board revealed that a filly named Phone Love tested positive for the sedative meprobamate following a Dec.
Carisoprodol is metabolized in the liver by CYP-450 2C19 to an active metabolite, meprobamate.
Drewes has found plenty of chemicals in treated wastewater--an antibiotic, a chemical used in perfume production, the muscle relaxant drug carisoprodol, and its metabolite meprobamate, among others.