Mesothelioma

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mesothelioma

[‚me·zō‚thē·lē′ō·mə]
(medicine)
A primary benign or malignant tumor composed of cells resembling the mesothelium.

Mesothelioma

 

a malignant tumor of the mesothelium. It is most frequently encountered in the pleura, less often in the pericardium or peritoneum.

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LATS2 staining showed frequent loss in both benign proliferations and mesotheliomas (Table).
Interestingly, while the tumor revealed histological features similar to the previous biopsy, the lung specimens showed involvement by a mesothelioma with epithelioid features (Figures 5 and 6).
There is no immunohistochemical marker with a high sensibility and specificity for malignant mesothelioma, often a combination of markers makes the diagnosis.
We report a case of 65 years old male with a history of chronic asbestos exposure who presented with left massive hemorrhagic pleural effusion which proved to be due to sarcomatoid type of malignant pleural mesothelioma (rare subtype).
Potentially useful serum markers for diagnosis and follow-up are the serum mesothelin-related protein (SMRP) which is elevated in more than 84% of mesotheliomas and has a 60% sensitivity at diagnosis.
Malignant mesothelioma is most commonly found in the pleura, peritoneum and pericardium, while mesothelioma involving the tunica vaginalis testis is very rare.
The immunohistochemical features were consistent with mesothelioma.
Pleural mesothelioma refers to a cancer of the lining of the lung (pleura).
More recently, Minato et al (7) found that while desmin stained mostly benign reactions, a small proportion of mesotheliomas also stained positively.
Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy.
A study of 21 deciduoid mesotheliomas (4) has shown that the high-grade subgroup (showing wide variation in size and shape of cells, frequent loss of cell cohesion, marked nuclear atypia, and mitotic activity > 5 per 10 high-power fields) had a much more aggressive clinical course, when compared to those deciduoid tumors that were more cohesive, less pleomorphic, and had low mitotic activity (Figure 3, A and B).
Mesotheliomas often present with recurrent serous effusions, which are submitted for cytologic evaluation.