metabolize

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metabolize

[mə′tab·ə‚līz]
(physiology)
To transform by metabolism; to subject to metabolism.
References in periodicals archive ?
The mother, an ultrarapid metabolizer, was excessively converting the codeine prodrug to the active morphine metabolite.
A genotyping test, the AmpliChip (Roche), which was approved by the Food and Drug Administration several months ago and is now available at many laboratories, subjects DNA from blood samples to microarray analysis to identify the polymorphisms associated with both slow and superfast CYP2D6 metabolizers.
The best way to identify patients who are slow or intermediate metabolizers of antipsychotic drugs is to perform a genetic analysis of the CYP2D6 alleles, which would cost about $300 per patients.
In previous studies individuals have been classified as poor, extensive, or ultrarapid CYP2D6 metabolizers according to their metabolic activity exerted on specific test drugs such as debrisoquine or sparteine (28-30).
For example, although rare among whites, as many as 20% of Chinese and Japanese are poor metabolizers through the CYPmp enzyme (K.
Prescreening sessions involved dextromethorphan phenotyping for the cytochrome P4502D6 enzyme to eliminate potential poor MDMA metabolizers prior to the study, and dobutamine echocardiography at three doses, as a safety test and to act as a comparator to MDMA.
17 /PRNewswire/ -- Nursing mothers can be tested with Roche Diagnostics' AmpliChip CYP450 Test to help their doctors determine whether they are ultra-rapid metabolizers of codeine.
Extensive metabolizers (EMs), who have normal enzymatic activity, can be distinguished from ultrarapid (ultraextensive) metabolizers (UMs), who have increased activity, and from poor metabolizers (PMs), who have very low or even absent enzymatic activity.
By contrast, the *2 and *3 alleles both show decreased CYP2C9 activity compared with that of the * 1 allele; thus the two subjects with a single copy of the CYP2C9*2 allele (genotype * 1/*2) could be extensive metabolizers with a normal rate of 2C9-substrate metabolism, and the one subject with a single copy of the CYP2C9*3 allele (genotype * 1/*3) could be a poor metabolizer with decreased rate of 2C9 substrate metabolism.
extensive metabolizers (EMs; CYP2C19*1/*1 and CYP2C19*1/ *X; where 'X' represents a mutant allele) and poor metabolizers (PMs; CYP2C19*X/*X) with marked inter-individual variations in the pharmacokinetics and pharmacodynamics of PPIs in the population.
Other urban metabolizers include sewage systems, landfills, domestic pets and pests like rats, which in some cities outnumber people.
Looking at a key gene involved in metabolizing caffeine, they were able to differentiate between individuals with a particular variation of the gene that made them "fast" metabolizers and those with another variant who were "slow" metabolizers.