metabolize

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metabolize

[mə′tab·ə‚līz]
(physiology)
To transform by metabolism; to subject to metabolism.
References in periodicals archive ?
PharmaPendium's Metabolizing Enzymes and Transporters Module allows for rapid, full text-search of literature from sources including approval documents from the Food and Drug Administration (FDA) and European Medicines Agency (EMA).
The new module supports early detection of viable drug candidates by providing the highest quality data and enabling comparative assessments of metabolizing enzyme and transporter activities, reducing chances of unpredictable adverse reactions and even late stage clinical failures.
One hypothesis of heart disease suggests that a heart can gradually fail after a nonfatal heart attack because the organ's muscle cells become inefficient at both taking up glucose and metabolizing fatty acids, says Clarke.
It is hypothesized that PPAR[alpha]-mediated activation of metabolizing enzymes leads to oxidative stress and free radical production.
Not only have these laboratories confirmed that MCT cell lines are a reliable tool to study induction of key drug metabolizing proteins, but more importantly, taken together these findings indicate that our immortalized hepatocytes can be employed to study the complex metabolism of new drug candidates and identify potential drug-drug interactions.
Under the Phase II grant, PolyGenyx plans to develop commercial assay kits for specific haplotypes of scientific/clinical significance, including those linked to cancer, asthma, diabetes, and drug metabolizing enzyme activity.
Martin and Muller's hypothesis assumes that the bacterium taken in by the archaeon could generate ATP by metabolizing organic molecules aerobically or anaerobically.
VARIAGENICS' pharmacogenomic analysis of the samples within this study may determine the individual contributions of metabolizing enzymes CYP3A4, CYP3A5, CYP3A7, and CYP3A43 to drug metabolism and efficacy in patients undergoing chemotherapeutic treatments.
FMO3 is a key human drug and chemical metabolizing enzyme that influences the biotransformation and disposition of many drugs and chemicals.
Then we came round to analyzing what had happened, and we found that I was not metabolizing the drug.
Human Hepatocytes, Induction of Drug Metabolizing Enzymes and Prediction of Drug-Drug Interactions
SignalGene will apply its unique pharmacogenomics platform for the genotyping of drug metabolizing enzymes (DMEs) on samples collected by Allied Clinical Research from participants to its clinical trials.