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The property exhibited by certain pure dyestuffs, chiefly basic dyes, of coloring certain tissue elements in a different color, usually of a shorter wavelength absorption maximum, than most other tissue elements.
The assumption of different colors or shades by different substances when stained by the same dye. Also known as metachromatism.



in biology, the property of cells and tissues that causes them to take on a color that differs from that of a dye. For example, in staining with thiazine dyes, the basic matter of connective tissue, tumor cells, and certain other cells are stained not blue or violet, the color of the dye, but red or pink. It is thought that metachromasia is caused by the polymerization of the dye molecules under the influence of free negative charges in the tissue.

References in periodicals archive ?
muscoides SPs physical and chemical characterization by agarose gel when Am-1 did not appear on gel and Am-3 had an intense metachromasia, as well as differing from other studied algae species SPs (Athukorala et al.
According to the histological section prepared from the pellet at day 21 of culture, the amount of metachromasia seemed to be higher in cultures with 0.
We observed a large peak corresponding to ~90% of the total hexuronic acid in the sample that eluted with ~400mM NaCl without showing any significant metachromasia.
Because of their high content of acidic radicals in their sulfated glycosaminoglycans, chondrocyte granules displayed metachromasia.
On histologic examination, granules exhibited a typical, although faint, metachromasia with toluidine blue and Giemsa stains (Fig 2D).
Metachromasia in the dye polymer interaction has been studied extensively since the discovery of this phenomenon in 1875 [1].
At 1 and 30 days after the treatment a significant increase of metachromasia was observed at doses of 150 and 600 mg of malathion.
It has often been stated that in experimental amyloidosis the metachromasia with gentian or methyl-violet is the only reaction which is distinct, the characteristic coloring with iodin or iodin sulphuric acid being absent, or much less pronounced (Bailey).