metachromatic leukodystrophy


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Related to metachromatic leukodystrophy: Krabbe disease, adrenoleukodystrophy

metachromatic leukodystrophy

[¦med·ə·krō′mad·ik ‚lü·kə′dis·trə·fē]
(medicine)
A hereditary degenerative disease transmitted as an autosomal recessive, due to sulfatase A deficiency, with excess accumulation of sulfated lipids responsible for metachromasia in various tissues. Abbreviated MLD. Also known as sulfatide lipidosis.
References in periodicals archive ?
Volumetric MRI data correlate to disease severity in metachromatic leukodystrophy.
Metachromatic leukodystrophy has predominant periventricular white matter involvement with tigroid pattern and spares the subcortical U fibres until late in the disease.
The report reviews pipeline therapeutics for Metachromatic Leukodystrophy (MLD) by companies and universities/research institutes based on information derived from company and industry-specific sources
Metachromatic leukodystrophy (MLD) is a rare inherited neurodegenerative lysosomal disease caused by deficient activity of arylsulphatase A (1).
Carrie Graham was touched by the plight of three-year-old Sameer Akeel, who has been diagnosed with the rare terminal illness metachromatic leukodystrophy.
Three months later, in February this year, Jack was diagnosed with a Metachromatic Leukodystrophy (MLD), a rare disorder which affects nerve endings in the brain.
Tests were carried out and on his third birthday Stephen was diagnosed with the degenerative condition Metachromatic Leukodystrophy.
When its onset is in adolescence, metachromatic leukodystrophy is commonly associated with psychotic symptoms and thought fragmentation, Dr.
These risk factors include hemolytic disease, congenital anomalies of the biliary tract, total parenteral nutrition, prolonged fasting, small-bowel resection and short-bowel syndrome, cystic fibrosis, inflammatory bowel disease, intercurrent infection, dehydration, multiple blood transfusions, prematurity, polycythemia, bronchopulmonary dysplasia, hypotension, prenatal calcium supplementation, furosemide or ceftriaxone therapy, hyperbilirubinemia, phototherapy, umbilical catheterization, metachromatic leukodystrophy, and Wilson's disease.
After all the tests, the doctor told me that James had metachromatic leukodystrophy (MLD).
Alzheimer's disease Pick's disease Huntington's disease Progressive supranuclear palsy Parkinson's disease (not all cases) Cerebellar degenerations Amyotrophic lateral sclerosis (ALS) (not all cases) Parkinson -- ALS-dementia complex of Guam and other island areas Rare genetic and metabolis disease (Hallervorden-Sparz, Kufs', Wilson's, late-onset metachromatic leukodystrophy, adrenoleukdystrophy)