metallothionein


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metallothionein

[mə‚tal·ō′thī·ə‚nēn]
(biochemistry)
A group of vertebrate and invertebrate proteins that bind heavy metals; it may be involved in zinc homeostasis and resistance to heavy-metal toxicity.
References in periodicals archive ?
Cloning and characterization of metallothionein cDNAs in the mussel Mytilus edulis L.
Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas.
Van den Broeck H, De Wolf H, Backeljau T and R Blust Effect of metal accumulation on metallothionein level and condition of the periwinkle Littorina littorea along the Scheldt estuary (the Netherlands).
Role of copper-specific metallothionein of the blue crab, Callinectes sapidus, in copper metabolism associated with degradation and synthesis of hemocyanin.
The specific chelating peptides such as metallothioneins (MTs) and phytochelatins (PCs) are responsible for the complexation of toxic metal ions.
Several reports suggest that the zinc transporter is distinct from the iron transporter, but the 5' promoter region of DMT1 contains several metal responsive element consensus sequences which are similar to the promoter of the metallothionein [II.
These include CD109, (4,5) caveolin 1 and 2, (6,7) podoplanin, (8) P-cadherin, (9,10) maspin, (11-13) nestin, (14) p75, (15-17) 14-3-3 sigma (stratifin), (18) smooth muscle actin (SMA), (19) p63, (20) CD10, (21) smooth muscle myosin heavy chains (SMMHCs), (22,23) h-caldesmon, (23) calponin, (23) S100, (24-26) basal type and high-molecular-weight cytokeratins, (27) glial fibrillary acid protein, (28,29) metallothionein, (12) Wilms tumor 1 protein, (30) CD44s, (31) and vimentin, (32) among others.
Daphnia adapts to high levels of cadmium by increasing a key protective molecule called metallothionein - a process, which also reduces their reproductive success.
Supplementation of dietary cysteine elevates kidney metallothionein in rats by a mechanism involving altered zinc metabolism.
Topics ranged from metallothionein to skutterudites, with much in between.
Their topics include cellular inorganic chemistry concepts and examples, essential and toxic metal transport in the liver, the transport and biological impact of manganese, metallothionein and metal homeostasis, the regulatory and signaling functions of zinc ions in human cellular physiology, ionic and molecular mimicry and the transport of metals, heavy metal transport and detoxification in crustacean gastrointestinal and renal epithelial cells, metals and cell adhesion molecules, and metal influences on immune function.
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