metanephrine


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Related to metanephrine: pheochromocytoma, Catecholamines

metanephrine

[‚med·ə′ne‚frən]
(biochemistry)
An inactive metabolite of epinephrine (3-O-methylepinephrine) that is excreted in the urine; it is recovered and measured as a test for pheochromocytoma.
References in periodicals archive ?
The patient became normotensive and plasma metanephrines improved, but did not return to normal.
However, metanephrine measurements are warranted to assess/ exclude their hormonal activity.
Plasma metanephrine levels were normal at the time of consultation and prior to surgery.
which are described as 3-hydroxy-2-methylpyridine-4,5-dicarboxylate, L-dopa, DL-dopa, metanephrine, and phosphoguanidinoacetate respectively.
2004) Measured urinary concentrations of MHPG-sulphate, nor- metanephrine, and metanephrine, salivary concentrations of cortisol and testosterone, assessment of mood status using POMS, an overtraining questionnaire, and muscle soreness ratings.
40) Measurement of 24-hour urinary catecholamines and their metabolites has been the screening test of choice, (43) but recent evidence suggests that measurement of plasma metanephrine and normetanephrine is a far more sensitive screen.
Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma.
Within the tumor itself, epinephrine (Epi) is metabolized to metanephrine and norepinephrine (NE) is metabolized to normetanephrine by the enzyme catechol-O-methyltransferase.
Subsequently, urinary free cortisol (UFC) (normal range: <110[micro]g), urinary normetanephrine (normal range: 88-444 [micro]g/day) and urinary metanephrine (normal range: 52-341 [micro]g/day) were measured and the 1 mg overnight dexamethasone suppression test (DST) was performed.
28) Elevated levels of urinary metanephrine or resting plasma catecholamines can suggest the diagnosis of pheochromocytoma.
3) Diagnosis may be made with 24 hr urine metanephrine or catecholamine measurement, 123I-metaiodobenzylguanidine scintigraphy (MIBG) scanning, or on pathological analysis after resection of an adrenal tumor.
dehydroepiandrosterone sulfate (DHEA-S), serum baseline 17-hydroxyprogesterone (17-0HP), urinary metanephrine, normetanephrine, vanilylmandelic acid (VMA) excretion, low-dose 2 mg dexamethasone suppression tests, plasma aldosterone and renin activity.