This precursor is transferred to certain gene "switches" that in turn increase the metastatic capacity
of cancer cells by activating a specific gene program.
The identified molecular target acts as a master switch and regulates multiple functions of breast cancer cells, including their growth, migration and metastatic capacity
Regardless of whether metastatic capacity
is acquired according to the tumor progression model, Brabetz and colleagues make an argument for "the existence of a dynamic component to human tumor progression.
The researchers will present data examining IgG's (GCAN101) efficacy in inhibiting the proliferation and metastatic capacity
of colon cancer in a mouse model.