(redirected from metastatic tumor)
Also found in: Dictionary, Thesaurus, Medical, Legal, Wikipedia.
Related to metastatic tumor: Cancer, metastasize


1. Pathol the spreading of a disease, esp cancer cells, from one part of the body to another
2. a rare word for metabolism



a secondary pathological focus arising from the transfer of a pathogenic principle (tumor cells, infectious agent) from the primary site of affection by the lymph or blood.

In the modern view, the term “metastasis” generally applies to the spread (dissemination) of malignant tumor cells; the spread of an infectious principle is usually described by the term “metastatic infectious focus.”

Benign tumors are also known to metastasize, and the capacity to do so is inherent in normal cells of various origin (in placental villi, adipose and hematopoietic bone-marrow cells). A distinctive feature of metastasizing tumor cells is the uncontrollable growth of the metastasis, relating it to primary foci of malignant growth. Metastatic tumor nodes retain other properties of primary tumors as well, such as microstructural features and the capacity to form the same products; however, metastatic nodes often have a more primitive structure and consist of functionally less mature cells than do the original tumors.

When tumor cells spread chiefly through the lymphatic vessels, metastases generally appear in the lymph nodes closest to the primary site. Although much research has been devoted to the routes and anatomical patterns of lymphogenous metastasis, the biological patterns of formation of lymphogenous metastases remain obscure. The mechanisms of hematogenous metastasis (to the lungs, liver, bones, and other viscera) are better understood. Four stages in the development of hematogenous metastasis are distinguished: (1) the detachment of cells from the primary tumor node and their penetration of the blood through the vascular wall; (2) the circulation of the tumor cells in the blood; (3) the attachment of the cells to the vascular wall and the start of intravascular growth; and (4) the rupture of the vascular wall by the tumorous masses and the subsequent growth of the metastasis into the tissue of the affected organ. The presence of metastasis indicates that a tumorous process has shifted from a local growth phase to a phase of generalization. A distinction is made between solitary metastasis, which generally can be removed surgically, and multiple metastases, which require combined treatment using radiation and chemotherapy.



Transfer of the causal agent (cell or microorganism) of a disease from a primary focus to a distant one through the blood or lymphatic vessels.
A transition of an electron or nucleon from one bound state to another in an atom or molecule, or the capture of an electron by a nucleus.
References in periodicals archive ?
All these results were correlated with an increase in the life span of metastatic tumor bearing animals treated with [beta]-carotene.
Most metastatic tumors appear as well-circumscribed, single or multiple nodules (Figure 5, D), but some neoplasms, such as lobular carcinoma of the breast and signet ring adenocarcinoma, tend to present as ill-circumscribed, firm areas that are almost invisible to the naked eye.
Positive immunostaining for CK7 was observed in from 80% to 95% of the tumor cells in both the primary and metastatic tumors in all of the cases (Table).
Injection of Allovectin-7(R) directly into tumors is designed to stimulate an immune response against both local and distant metastatic tumors.
This is one of the biggest improvements in survival we have seen in patients with adult solid metastatic tumors," Dr.
Funded by the National Cancer Institute through the company's first NCI grant awarded December last year, its lead candidate drug Vicrostatin was combined with a drug-eluting gel and applied into the peritoneum for sustained release of the drug directly to ovarian cancer metastatic tumors.
This technology enables the molecular analysis of tumor DNA shed from primary and metastatic tumors, found circulating in the blood of patients.
Metastatic tumors involving the temporal bone usually spread from the breast (18% of cases), lung (12%), kidney (10%), stomach (8%), or larynx (5%).
We are extremely pleased to provide innovative new treatment options for the many patients suffering from painful metastatic tumors of the vertebral body.
Our results show that laser immunotherapy could have potential for the treatment of metastatic tumors by inducing tumor-specific, long-lasting immunity.
Identification of the primary site remains challenging and elusive in metastatic cases due in part to inherent biological characteristics of many metastatic tumors.
This tumor must be differentiated from other types of lesions including myxomas, true cardiac lipomas, liposarcomas, parietal thrombi, metastatic tumors and amyloidosis that appear as septal tumor mass.