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Related to metastatic tumor: Cancer, metastasize


1. Pathol the spreading of a disease, esp cancer cells, from one part of the body to another
2. a rare word for metabolism



a secondary pathological focus arising from the transfer of a pathogenic principle (tumor cells, infectious agent) from the primary site of affection by the lymph or blood.

In the modern view, the term “metastasis” generally applies to the spread (dissemination) of malignant tumor cells; the spread of an infectious principle is usually described by the term “metastatic infectious focus.”

Benign tumors are also known to metastasize, and the capacity to do so is inherent in normal cells of various origin (in placental villi, adipose and hematopoietic bone-marrow cells). A distinctive feature of metastasizing tumor cells is the uncontrollable growth of the metastasis, relating it to primary foci of malignant growth. Metastatic tumor nodes retain other properties of primary tumors as well, such as microstructural features and the capacity to form the same products; however, metastatic nodes often have a more primitive structure and consist of functionally less mature cells than do the original tumors.

When tumor cells spread chiefly through the lymphatic vessels, metastases generally appear in the lymph nodes closest to the primary site. Although much research has been devoted to the routes and anatomical patterns of lymphogenous metastasis, the biological patterns of formation of lymphogenous metastases remain obscure. The mechanisms of hematogenous metastasis (to the lungs, liver, bones, and other viscera) are better understood. Four stages in the development of hematogenous metastasis are distinguished: (1) the detachment of cells from the primary tumor node and their penetration of the blood through the vascular wall; (2) the circulation of the tumor cells in the blood; (3) the attachment of the cells to the vascular wall and the start of intravascular growth; and (4) the rupture of the vascular wall by the tumorous masses and the subsequent growth of the metastasis into the tissue of the affected organ. The presence of metastasis indicates that a tumorous process has shifted from a local growth phase to a phase of generalization. A distinction is made between solitary metastasis, which generally can be removed surgically, and multiple metastases, which require combined treatment using radiation and chemotherapy.



Transfer of the causal agent (cell or microorganism) of a disease from a primary focus to a distant one through the blood or lymphatic vessels.
A transition of an electron or nucleon from one bound state to another in an atom or molecule, or the capture of an electron by a nucleus.
References in periodicals archive ?
1, 4, 10-13) In the present study metastatic tumors (58%) were more frequently encountered than primary tumors.
Cytokeratin 7 staining was positive in both the primary and metastatic tumors of all the cases studied.
As the indication range of open decompression surgery is narrow, most patients who have spinal metastatic tumor or vertebral hemangioma in more than two segments often go untreated; moreover, patients with advanced tumors are difficult to tolerate open decompression surgery due to heavy trauma and multiple complications.
This article emphasizes on detailed dento alveolar examination and early diagnosis for finding the primary focus of metastatic tumor, which will help in a better prognosis of patients.
The presence of a metastatic tumor is a poor prognostic indicator for a person with cancer, since metastasized cancer is usually resistant to curative treatment.
Determination of the effect of [beta]-carotene on the survival rate of metastatic tumor bearing animals
CCC represents a highly aggressive and metastatic tumor type and currently no effective systemic therapy regimen exists.
Table 1: Frequency of different Classes of Benige Malignant of Tumour (148) CLASSES OF TUMOR BENIGN MALIGNENT Tumor of Surface epithelium 91 20 Germ cell tumor 19 4 Sex cord stromal tumor 6 3 Metastatic tumor 0 1 TOTAL 116 (78.
The patient underwent radiofrequency ablation of a large (2 cm in size) metastatic tumor in the lungs in July 2004.
The potential ways of metastatic tumor spread to the spermatic cord and/or intrascrotal contents include retrograde lymphatic extension, direct invasion or extension, arterial embolism, retrograde venous extension or embolism, and retrograde spermiduct extension.
Scientists using a three-dimensional cell culture system have identified a mechanism by which dormant, metastatic tumor cells can begin growing again after long periods of inactivity.