Hexamethylenetetramine

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Hexamethylenetetramine

 

hexamine, or urotropine, colorless crystals with a sweet taste that carbonize at 280° C and sublime in vacuum above 230° C. Hexamethylenetetramine is highly soluble in water and carbon disulfide, moderately in alcohol and chloroform, and slightly in ether and benzene.

Hexamethylenetetramine is prepared by condensing ammonia with formaldehyde: 4NH3 + 6CH2O⇌(CH2)6N4 + 6H2O.

This reaction is reversible and under certain conditions the equilibrium may be shifted toward the left, which makes it possible to use hexamethylenetetramine as a convenient formaldehyde source (for example, in the production of ureaformaldehyde resins). Hexamethylenetetramine is also used in the production of the powerful explosive hexogen, in analytical chemistry (for example, in the preparation of buffer solutions), and as a smokeless solid fuel (so-called solid alcohol). Hexamethylenetetramine is a medicinal preparation of the antiseptic variety. Its antimicrobial action is due to formaldehyde formation from the decomposition of hexamethylenetetramine in acid media. Hexamethylenetetramine is used internally in powders, tablets, and solutions, as well as intravenously in infectious diseases, particularly for urinary tract infections. It was first synthesized by A. M. Butlerov in 1860.

References in periodicals archive ?
The commonly used fungal stains are: Gomori methenamine silver (GMS), Periodic acid-Schiff (PAS), Gridley's method and Mucicarmine.
The pelleted samples and the homogenate obtained were used for culture and Gomori methenamine stain, and 0.
Abbreviations: dx, diagnosis; GMS, Gomori methenamine silver; IF, immunofluorescence; post-op, postoperative.
Sections were prepared and stains used included haematoxylin and eosin (HandE) Periodic acid Schiff (PAS) Methenamine silver (MS) and reticulin stain (RS).
Also, people who have suffered from two to three UTIs may be prescribed methenamine, an antibiotic that changes the pH concentration to make it less attractive to bacteria.
Methenamine is a drug that may help prevent bladder infections.
For confirmation, staining was carried out with periodic acidSchiff (PAS) (figure IB) and Gomori methenamine silver (figure 1C and ID), which showed organisms with multiple septa in the cytoplasm.
Hence, special stains like Periodic acid Schiff stain (PAS) and Grocott's methenamine silver stain (GMS) were used, which showed occasional septate fungal hyphae (Figure 1, arrow).
jirovecii in single forms or typical clusters (one every ten fields at x20 magnification), demonstrated by GrocottGomori methenamine silver stain (Fig.
Higher magnification shows fungal elements with septate, branching hyphal forms which stain positively with traditional fungal stains such as Grocott-Gomori's methenamine silver (GMS) and Periodic acid-Schiff (PAS).
Bacterial concretions consisted of large masses of filamentous, presumed Actinomyces organisms that were identified with the Grocott's methenamine silver stain.
The other is the use of Methenamine mandelate (Mandelamine) with sulfa antibiotics (Bactrim or Septra), which can result in crystals forming in your bladder.