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methotrexate |
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methotrexate, drug used in halting the growth of actively proliferating tissues. Introduced in the 1950s, it is used in the treatment of leukemia leukemia (l ..... Click the link for more information. , psoriasis psoriasis (sôrī`əsĭs), occasionally acute but usually chronic and recurrent inflammation of the skin. ..... Click the link for more information. , and non-Hodgkin's lymphoma lymphoma, non-Hodgkin's, any cancer of the lymphoid tissue (see lymphatic system ) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present. ..... Click the link for more information. . By binding to an enzyme enzyme, biological catalyst . The term enzyme comes from zymosis, the Greek word for fermentation , a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists. ..... Click the link for more information. that controls the metabolism of folic acid, methotrexate interferes with synthesis of nucleic acids nucleic acid, any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis. ..... Click the link for more information. and therefore with tissue cell reproduction. Because of its immunosuppressive qualities, it is also used in the treatment of rheumatoid arthritis arthritis, painful inflammation of a joint or joints of the body, usually producing heat and redness. There are many kinds of arthritis. In its various forms, arthritis disables more people than any other chronic disorder. ..... Click the link for more information. . |
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In both the RAPID 1 (027) and RAPID 2 (050) studies CIMZIA(TM), in combination with methotrexate, demonstrated superiority to placebo, and a statistically significant improvement in the signs and symptoms of rheumatoid arthritis as measured by all American College of Rheumatology (ACR) scores: ACR20, 50, and 70. Tokyo, Japan, July 24, 2006 - (JCN) - Tanabe Seiyaku launched Methotrexate tablets 2mg TANABE (generic name: methotrexate), an anti-rheumatic drug for the indication of rheumatoid arthritis (RA) only if there is no indication of improvement when conventional treatment therapies such as nonsteroidal anti-inflammatory agents and other anti-rheumatic agents are used, on July 21. Treatment with corticosteroids and methotrexate likely facilitated development of amebic infection by compromising the patient's immune system. |
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methotrexate