methotrexate


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methotrexate,

drug used in halting the growth of actively proliferating tissues. Introduced in the 1950s, it is used in the treatment of leukemialeukemia
, cancerous disorder of the blood-forming tissues (bone marrow, lymphatics, liver, spleen) characterized by excessive production of immature or mature leukocytes (white blood cells; see blood) and consequently a crowding-out of red blood cells and platelets.
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, psoriasispsoriasis
, occasionally acute but usually chronic and recurrent inflammation of the skin. The exact cause is unknown, but the disease appears to be an inherited, possibly autoimmune disorder that causes the overproduction of skin cells.
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, and non-Hodgkin's lymphomalymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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. By binding to an enzymeenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
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 that controls the metabolism of folic acid, methotrexate interferes with synthesis of nucleic acidsnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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 and therefore with tissue cell reproduction. Because of its immunosuppressive qualities, it is also used in the treatment of rheumatoid arthritisarthritis,
painful inflammation of a joint or joints of the body, usually producing heat and redness. There are many kinds of arthritis. In its various forms, arthritis disables more people than any other chronic disorder.
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.

methotrexate

[‚meth·ə′trek‚sāt]
(pharmacology)
References in periodicals archive ?
Baricitinib plus methotrexate also demonstrated significant inhibition of progressive radiographic structural joint damage measured using van der Heijde modified Sharp Score versus methotrexate alone at weeks 24 and 52
The most recent data on methotrexate come from an open-label trial known as TICOPA, which used a tight control treatment paradigm through 48 weeks of treatment.
Like methotrexate, these particles also block DHFR; as they compete with the drug they alter the colour of light passing through the sample.
In addition to abdominal cramping and other well-known issues, methotrexate could damage surrounding fallopian tube and may cause ectopic pregnancies to enlarge, Dr.
As a rheumatologist, I believe Rasuvo will offer patients the opportunity to maximize the benefit they get from methotrexate, Ruderman said, adding that the drug s dosing flexibility, in particular, will be very helpful, as RA patients do not all respond equally to methotrexate, making it important to select a treatment regimen that is appropriate for the patient s condition.
5 percent in those treated with methotrexate alone, while 55 sucess in those treated with TwHF alone and just under 77 percent in those treated with both.
Methotrexate is the "gold-standard" drug for people with mild to moderate rheumatoid arthritis and is widely taken and largely well-tolerated.
Methotrexate itself is in fact almost undetectable in the serum 24 hours after administration.
To avoid adding staff and instrumentation for a new methotrexate assay, we developed a method to quantify methotrexate and other immunosuppressants in the same assay.