methotrexate


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methotrexate,

drug used in halting the growth of actively proliferating tissues. Introduced in the 1950s, it is used in the treatment of leukemialeukemia
, cancerous disorder of the blood-forming tissues (bone marrow, lymphatics, liver, spleen) characterized by excessive production of immature or mature leukocytes (white blood cells; see blood) and consequently a crowding-out of red blood cells and platelets.
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, psoriasispsoriasis
, occasionally acute but usually chronic and recurrent inflammation of the skin. The exact cause is unknown, but the disease appears to be an inherited, possibly autoimmune disorder that causes the overproduction of skin cells.
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, and non-Hodgkin's lymphomalymphoma, non-Hodgkin's,
any cancer of the lymphoid tissue (see lymphatic system) in which the Reed-Sternberg cells characteristic of Hodgkin's disease (the other category of lymphoma) are not present.
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. By binding to an enzymeenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
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 that controls the metabolism of folic acid, methotrexate interferes with synthesis of nucleic acidsnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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 and therefore with tissue cell reproduction. Because of its immunosuppressive qualities, it is also used in the treatment of rheumatoid arthritisarthritis,
painful inflammation of a joint or joints of the body, usually producing heat and redness. There are many kinds of arthritis. In its various forms, arthritis disables more people than any other chronic disorder.
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.

methotrexate

[‚meth·ə′trek‚sāt]
(pharmacology)
References in periodicals archive ?
The earlier findings also suggested that flu vaccine uptake is highest in those who stop methotrexate after vaccination.
Key Words: Methotrexate, Acitretin, Chronic Plaque psoriasis
At our hospital, 25 patients had received single-dose methotrexate therapy for ectopic pregnancy.
Based on the clinical and histological findings, methotrexate was stopped with no additional drugs started.
Gottheil and her associates particularly focused on 1,189 early RA patients with moderate to severe disease activity enrolled in CATCH during 2007-2012 who received methotrexate and had never previously received a biologic drug.
All three cases have been under regular follow-up, and are in remission since complete stoppage of their methotrexate therapy.
Women with a daily increase of 15% or more were treated with methotrexate.
KEY WORDS: Plaque psoriasis Methotrexate Efficacy Remission.
Methotrexate is a drug that has seen wide applications in the treatment of malignant diseases.
10]-methylpteroic acid, a minor (<5%) endogenous methotrexate metabolite and the major (>98%) product of pharmacologic inactivation of methotrexate with car-boxypeptidase [G.
He was diagnosed with psoriatic arthritis in 2006, for which he had used methotrexate 10 mg per week for the past three years.