methyl transferase


Also found in: Medical.

methyl transferase

[′meth·əl ′tranz·fə‚rās]
(biochemistry)
Any of a group of enzymes which catalyze the reaction of S-adenosyl methionine with a suitable acceptor to yield the methylated acceptor molecule and S-adenosyl homocysteine.
References in periodicals archive ?
Ethanol also interferes with the metabolism of the amino acid methionine into a compound called S-adenosyl-methionine (SAMe) by several different methyl transferase reactions.
4) One such enzyme called EZH2 has intrinsic histone H3K27 methyl transferase activity; it assembles into a multiprotein complex called polycomb repressive complex 2 (PRC2) that, together with another protein complex (i.
24(25)] sterol methyl transferase inhibitors and their combinations with ketoconazole.
24(25)] sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyl transferase asl and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells.
Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyl transferase activity and 6 thioguanine nucleotides concentrations.
In neurons, a specific histone methyl transferase has been identified that has a key role in regulating the expression of genes that code for neuron-specific proteins in adult brain; this enzyme seems to participate in at least two neuron-specific pathways (Anne Schaefer, The Rockefeller University, New York, USA).
Steven Gore, associate professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, who has been investigating SNDX-275 in combination with the DNA methyl transferase inhibitor azacitidine.
Discovery on Target offers attendees the opportunity to explore current "hot" targets, including GPCRs, Kinases and Histone Deacetylases, as well as to discover the "new kids on the block" which show a very promising future, such as Ubiquitin, Histone Methyl Transferases and PI3K.
The enzymes encoded by floral-scent genes fall into a few functional categories with names such as synthases, methyl transferases, and carboxymethyltransferases.
By delivering all the advantages of well-recognized PathHunter[R] cell-based chemiluminescent assay platform, InCELL Hunter technology enables users to screen for compound binding in live cells against a wide number of drug targets including serine-threonine kinases, bromo-domains, methyl transferases and other emerging targets.
He is specifically interested in transcription factor, DNA methyl transferases and nucleotide excision repair.