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methylate
(redirected from methylator)

   Also found in: Dictionary/thesaurus, Medical 0.01 sec.
methylate [′meth·ə‚lāt]
(organic chemistry)


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In the study, the researchers examined tumour tissue from 553 colorectal cancer patients, specifically looking for associations between self-reported hormone use and a specific DNA methylation pattern, called the CpG island methylator phenotype, or BRAF gene mutations.
1 CpG island methylator phenotype (CIMP) is a subset of colorectal carcinoma (CRC) characterized by concordant hypermethylation of multiple promoter CpG island loci2 and peculiar clinicopathologic findings, such as close association with microsatellite instability (MSI), proximal tumor location, female preponderance, high frequency of mutation of the protooncogene BRAF, and low frequency of mutation of the proto- oncogene KRAS.
These findings are consistent with previous reports that found adipocytes to be inefficient methylators of iAs (Walton et al.
 
 
 
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