methylate

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methylate

[′meth·ə‚lāt]
(organic chemistry)
References in periodicals archive ?
Genetic polymorphisms in one-carbon metabolism: Associations with CpG island methylator phenotype (CiMP) in colon cancer and the modifying effects of diet.
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.
An example of this would be CpG island methylator phenotypes, described for several types of cancer.
In the study, the researchers examined tumour tissue from 553 colorectal cancer patients, specifically looking for associations between self-reported hormone use and a specific DNA methylation pattern, called the CpG island methylator phenotype, or BRAF gene mutations.
All the samples analysed showed the absence of a methylator phenotype in MDS.
Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors.
Former and current smokers were much more likely than never smokers to develop colorectal cancers associated with a CpG island methylator phenotype and/or a BRAF mutation in the analysis of data and tissue samples from 37,399 women enrolled in the Iowa Women's Health Study.
As we previously have observed (12), markers were hypermethylated in a common subset of CRC samples(88% of CRC samples with a PMR of >10% for any marker) and showed a typical CpG island methylator phenotype (20).
The most frequent cause of sporadic MSI is acquired promoter hypermethylation of MLH1, (51) which often occurs in the context of global hypermethylation of gene promoters known as the CpG island methylator phenotype.
The role of 6-TGN for assessing compliance, and in combination with 6-MMP to assess drug-failure attributable to high methylator status, seems well accepted (21, 22) but not yet substantiated by rigorous study data.
CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies.
13) Three mechanisms that increase the diversity of gene expression have been identified in CRC: microsatellite instability (MSI), chromosomal instability (CIN), and CpG island methylator phenotype (CIMP).