Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin K inhibitor odanacatib: demethylation of a methylsulfonyl
moiety as a major metabolic pathway.
Abbreviations used: EDTA, ethylenediamine tetraacetate; PAGE, polyacrylamide gel, electrophoresis; PMSF, phenyl- methylsulfonyl
fluoride; SDS, sodium dodecyl sulphate
No information was obtained on the methylsulfonyl
Distribution of PCB congeners, DDE, hexachlorobenzene, and methylsulfonyl
metabolites of PCB and DDE among various fractions of human blood plasma.
Yumoto (1999), "Reduction of Thyroid Hormone Levels by Methylsulfonyl
Metabolites of Tetra- and Pentachiorinated Biphenyls in Male Sprague-Dawley Rats," Toxicological Sciences, 48(1):51-54.
In a smaller subset, we measured methylsulfonyl
metabolites, but their levels were far lower than the OH-PCBs.
3] concentrations and levels of 14 PCBs, 7 hydroxylated PCBs (HO-PCBs), all methylsulfonyl
metabolites of PCBs ([MeSO.
Hydroxylated and methylsulfonyl
polychlorinated biphenyl metabolites in albatrosses from Midway Atoll, North Pacific Ocean.
An AOAC Working Group on MSM, chaired by David Lakey, president, Cardinal Nutrition, was created to drive and ensure the development of standardized analytical method(s) for MSM (dimethyl sulfone, also known as methylsulfonyl
Knaus, Design and synthesis of Celecoxib and Rofecoxib Analogues as Selective Cyclooxygenase-2 (COX-2) Inhibitors: Replacement of Sulfonamide and methylsulfonyl
pharmacophores by an Azido Bioisostere, J.
The oxidation of 8-(thiomethyl) 4,4-difluoro-3,5- dimethyl-4-bora-3a,4a-diaza-s-indacene 6 with m-CPBA gave methylsulfonyl