microangiopathy


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microangiopathy

[‚mī·krō‚an·jē′äp·ə·thē]
(medicine)
The development of lesions in small blood vessels throughout the body.
References in periodicals archive ?
This may be explained on the basis of decrease in the host defence mechanism, and decreased phagocytic activity, which is noticed immediately in uncontrolled diabetes and these changes do not require much longer time to develop unlike microangiopathy.
Thrombotic microangiopathy (TMA) refers to conditions that cause microvascular thrombosis and result in microangiopathic haemolytic anaemia with presence of fragmented red cells on peripheral blood, thrombocytopenia and end organ damage.
Microangiopathy and derangements in the immune function are known consequences of hyperglycemia, but the way in which these systemic alterations may affect pulmonary function has been scarcely investigated.
Thrombotic microangiopathy (TMA) with predominantly chronic features is found in up to 5% of tumor nephrectomy specimens.
Nasdaq: ALXN) today announced the presentation of two-year data that highlight the long-term benefits of chronic Soliris([R]) (eculizumab) therapy in patients with atypical hemolytic uremic syndrome (aHUS), an ultra-rare genetic disease characterized by thrombotic microangiopathy (TMA), the formation of blood clots in small blood vessels throughout the body.
Delay in diagnosing the thrombotic microangiopathy in the brain due to neuraminidase aHUS might have caused the obstruction for the absorption of CSF leading to hydrocephalus in our case.
14,16-18) We have encountered 5 cases with glomerular thrombotic microangiopathy (TMA) associated with bevacizumab treatment.
Soliris is also approved in the United States as the first and only treatment for patients with atypical hemolytic uremic syndrome (aHUS), a debilitating, ultra-rare, life-threatening and chronic genetic disorder characterized by complement-mediated thrombotic microangiopathy (blood clots in small vessels).
Long standing diabetes causes changes in the interstitium of the lungs as a part of diabetic microangiopathy (3) and non-enzymatic glycalation of extracellular matrix (4) there is also acceleration of aging process in the connective tissue of the lungs and modification of alveolar surfactant (5)