The enlargement in the breadth of transition was used to suggest a lack of miscibility or microheterogeneity
of the films forming polymer (18), (19).
In addition, some microheterogeneity
is observed within populations (12).
Here, we report on biomarker development studies undertaken to characterize protein microheterogeneity
and evaluate its use in creating multidimensional biomarker views related to the pathobiologies of T2D and CVD comorbidities.
of erythropoietin carbohydrate structure.
However, all three proteins exhibit structural microheterogeneity
that gives rise to protein variants that are not detected by conventional tests.
Among their topics are screening newborns for cystic fibrosis, cystic fibrosis and respiratory viral infections, neutrophil elastase-mediated modulation of pathophysiology in cystic fibrosis lung disease, genotype heterogeneity of the molecular basis of cystic fibrosis as the paradigm of Lithuanian population genetic testing, serum transferrin microheterogeneity
in cystic fibrosis, recommendation for good practice and analytical criteria of the methods used in the sweat test, ocular surface changes in patients with cystic fibrosis, and managing arthritis related to cystic fibrosis.
The primary amino acid sequence of the FSH[beta] subunit was earlier determined from human pituitary glands, and consists of 118 amino acid residues with a predominant proportion of molecules having 108 residues due to microheterogeneity
at the N[H.
In later stages, the focus is to determine the microheterogeneity
of the product and any impurities associated with the manufacturing process.
of the murine major histocompatibility antigens.
pemaquidensis strains suggests that rRNA gene sequence microheterogeneity
is commonplace in this species, and ongoing work (O'Kelly & collaborators, unpublished) is consistent with this interpretation.
It is critical to rationalize the relevance of the microheterogeneity
that newer technologies are detecting.
Certification of "traceable" standards that can be sold to other laboratories is time-consuming and costly, especially when the extent of microheterogeneity
within each specimen becomes part of the uncertainty assigned to thc certified values.