Microsome

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microsome

[′mī·krə‚sōm]
(cell and molecular biology)
A fragment of the endoplasmic reticulum.
A minute granule of protoplasm.

Microsome

 

a fragment in the endoplasmic network (bubbles about 1,000 angstroms diameter), formed when cells are destroyed during the homogenization of animal and plant tissues. The microsome fraction of the homogenate is isolated by differential centrifugation. There are two types of microsomes: smooth-surfaced and rough-surfaced (as a result of the distribution of ribosomes on the latter). Before the technique of separating cellular homogenates was perfected, the microsome fraction also included mitochondria.

References in periodicals archive ?
2013) Crystal structure of microsomal prostaglandin [E.
The specificity of the optimized MRM transitions was confirmed by analyzing the tryptic digests of microsomal samples of a) Sf9 cells containing recombinant CYP2F1, b) control Sf9 cells, c) 2A13/[2F1-TG.
Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function," The Journal of Clinical Investigation, vol.
Microsomal NDMA-dI activity was determined according to the method of Venkatesan et al.
Influence of deltamethrin on microsomal cytochrome P-450 activity of susceptible house flies (Musca domestica vicina L.
This follows the approval of lomitapide (Juxtapid), a microsomal triglyceride transfer protein (MTP) inhibitor approved in December, to reduce LDL cholesterol, total cholesterol, apolipoprotein B, and non-HDL cholesterol in patients with HoFH.
Expression of NQO-1, GST-alpha, gamma-glutamylcysteine synthetase-heavy and -light chains, and microsomal GST was assessed by Northern blot analysis.
Researchers at the Perelman School of Medicine at the University of Pennsylvania, who led the study, revealed that lomitapide, a first-in-class microsomal triglyceride transfer protein (MTP) inhibitor, substantially and stably reduced LDL cholesterol (the "bad" cholesterol) in patients with the orphan disease homozygous familial hypercholesterolemia (HoFH).
Methods: A total of 106 HCV infected individuals (not on any antiviral therapy), were screened for laboratory evidence of autoimmunity (ANA, SMA, AMA, Anti LKM, Anti GPC, Anti Thyroid microsomal and RA factor).
6] Human genes: MTTP, microsomal triglyceride transfer protein; SAR1BB, SAR1 homolog B (S.
7) In contrast, higher levels of PGE2 produced in response to pro- inflammatory cytokines depend upon the coordinated activity of sPLA2, COX-2, and microsomal (m) PGES, which may participate in pathogenic tissue injury.

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