Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal
prostaglandin E synthase-1.
Anti-mitochondrial, anti-smooth muscle and anti-liver kidney microsomal
antibodies were negative.
Obach, "Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal
Intrinsic Clearance Date: an Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes," Drug.
Given the importance of hepatic microsomal
degradation of CHQ, an alteration in liver morphology by the antimalarial (56) is likely to result in an impairment of its metabolism and an increase in its circulating levels.
The supernatant was centrifuged at 5500xg (15 min) to remove mitochondria and finally at 30,000xg (45 min) to obtain a crude microsomal
fraction (16Kp) and cytosol (16Ks).
Findings showed microsomal
membrane-prepared fractions from HaCaT cell cultures, with 0, 1, 2 and 4 ug/well of cycloheximide, solubilized synthetic melanin.
A human liver microsomal
preparation, rich in cytochrome P450 oxidase activity, simulates passage of a drug or plant extract through the body.
Decreased biotransformation occurs in newborns due to underdevelopment of hepatic microsomal
All hydantoins induce production of liver microsomal
enzymes (the cytochrome P-450 system), thereby accelerating the metabolism of concomitantly administered drugs.
McCay's own work, with microsomal
membranes, suggests glutathione -- not the respiratory system -- donates vitamin-rejuvenating electrons there.
They target several novel pathways of disease by inhibiting the activity of specific enzymes such as ROCK2 (Rho-associated coiled-coiled kinase 2), the target of SLx-2119; MTP (enterocytic microsomal
triglyceride transfer protein), the target of SLx-4090; and PDE5 (phosphodiesterase 5), the target of SLx-2101.
Many of the chronic effects of alcohol is through it's metabolism by alcohol dehydrogenase and microsomal
pathways of ethanol oxidizing system.