Microsome

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Related to microsomal: microsomal enzymes, Microsomal Ethanol Oxidizing System, microsomal fraction, microsomal monooxygenase

microsome

[′mī·krə‚sōm]
(cell and molecular biology)
A fragment of the endoplasmic reticulum.
A minute granule of protoplasm.

Microsome

 

a fragment in the endoplasmic network (bubbles about 1,000 angstroms diameter), formed when cells are destroyed during the homogenization of animal and plant tissues. The microsome fraction of the homogenate is isolated by differential centrifugation. There are two types of microsomes: smooth-surfaced and rough-surfaced (as a result of the distribution of ribosomes on the latter). Before the technique of separating cellular homogenates was perfected, the microsome fraction also included mitochondria.

References in periodicals archive ?
Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1.
Obach, "Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Date: an Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes," Drug.
Given the importance of hepatic microsomal degradation of CHQ, an alteration in liver morphology by the antimalarial (56) is likely to result in an impairment of its metabolism and an increase in its circulating levels.
The supernatant was centrifuged at 5500xg (15 min) to remove mitochondria and finally at 30,000xg (45 min) to obtain a crude microsomal fraction (16Kp) and cytosol (16Ks).
Findings showed microsomal membrane-prepared fractions from HaCaT cell cultures, with 0, 1, 2 and 4 ug/well of cycloheximide, solubilized synthetic melanin.
A human liver microsomal preparation, rich in cytochrome P450 oxidase activity, simulates passage of a drug or plant extract through the body.
Decreased biotransformation occurs in newborns due to underdevelopment of hepatic microsomal components (5).
All hydantoins induce production of liver microsomal enzymes (the cytochrome P-450 system), thereby accelerating the metabolism of concomitantly administered drugs.
McCay's own work, with microsomal membranes, suggests glutathione -- not the respiratory system -- donates vitamin-rejuvenating electrons there.
They target several novel pathways of disease by inhibiting the activity of specific enzymes such as ROCK2 (Rho-associated coiled-coiled kinase 2), the target of SLx-2119; MTP (enterocytic microsomal triglyceride transfer protein), the target of SLx-4090; and PDE5 (phosphodiesterase 5), the target of SLx-2101.
Many of the chronic effects of alcohol is through it's metabolism by alcohol dehydrogenase and microsomal pathways of ethanol oxidizing system.

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