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microtubule

   Also found in: Dictionary/thesaurus, Medical, Acronyms, Wikipedia, Hutchinson 0.01 sec.

microtubule

Tubular structure enclosed by a membrane found within animal and plant cells. Of varying length, they have several functions. They help give shape to many cells and are major components of cilia and flagella, participate in the formation of the spindle during cell division (mitosis), and assist the movement of vesicles from the cell bodies of nerve cells toward the ends of those cells' long extensions (axons) and back to the cell bodies.


microtubule [¦mī·krō′tüb·yül]
(cell and molecular biology)
One of the hollow tubelike filaments found in certain cell components, such as cilia and the mitotic spindle, and composed of repeating subunits of the protein tubulin.


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The new findings suggest that loss of microtubule organization might contribute to the devastating symptoms of Duchenne muscular dystrophy, information that will hopefully lead to the development of therapies to combat the disease.
Contributors overview compounds that interact with tubulin, then address molecular mechanisms, microtubule dynamics, post translational modification, isotypes, tubulin proteomics in cancer, structures, destabilization, molecular features of the interaction of colchicines and related structures with tubulin, mechanisms of resistant to drugs that interfere with microtubule assembly, microtubule damaging agents, microtubule targeting agents, and associations with tau proteins.
The so-called 2-prime site binds to support structures inside cells called microtubules, stopping the cells from dividing.
 
 
 
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