We further evaluated the role of the pathway as a mediator of metal-induced toxicity using the in vitro midbrain
micromass culture assay.
If it were possible to take MRIs of babies' midbrains
before these babies started 'exercising' and then follow these babies through life, it may be that inherent, genetically-based differences in midbrain
size detected soon after birth will influence how much they would be likely to exercise as adults," Garland added.
The tiny unborn brain at eight weeks does already contain midbrain
cells that are able to produce the chemical dopamine, which is responsible for some of the more refined, sophisticated forms of adult voluntary movement.
BLSI and its collaborating scientists were the first to detect an easily measurable, consistent, and reproducible abnormality in the midbrains
of individuals with expertly-diagnosed ADHD.
All were significantly augmented in the midbrains
of mice treated with rapamycin.
Coffey of the University of Sheffield, England, discovered that patches of retinal cells grafted atop the midbrains
of rats can grow and connect with brain areas that process and respond to visual stimuli.