mineralocorticoid


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mineralocorticoid

[¦min·rə·lō′kȯrd·ə‚kȯid]
(biochemistry)
A steroid hormone secreted by the adrenal cortex that regulates mineral metabolism and, secondarily, fluid balance.
References in periodicals archive ?
The team from Bochum has examined 80 subjects, 50 percent of whom were given a drug blocking mineralocorticoid receptors in the brain.
Addison's disease, or primary adrenal insufficiency, is a chronic disorder of the adrenal cortex resulting in inadequate production of glucocorticoids and mineralocorticoids.
Table 1 Examples of the Clinical Use of Glucocorticoids Pulmonology asthma, sarcoidosis Rheumatology rheumatoid arthritis, systemic lupus erythematosus, myositis, gout Gastroenterology ulcerative colitis, Crohn's disease Immunology allergic diseases Endocrinology replacement therapy in glucocorticoid deficiency Nephrology glomerulonephritis Oncology lymphoproliferative disorders Dermatology connective tissue and immunobullous diseases, vasculitis, dermatitis Neurology multiple sclerosis, myasthenia gravis Ophthalmology uveitis, iritis, scleritis Table 2 Approaches to Optimizing Treatments with Glucocorticoids (20) Synthesize GCs with decreased mineralocorticoid but increased anti-inflammatory activity e.
Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.
Changes in glucocorticoid and mineralocorticoid receptors of liver and kidney cytosols after pathologic stress and its regulation in rats.
A Novel Nonsense Mutation of the Mineralocorticoid Receptor Gene in a Swedish Family with Pseudohypoaldosteronism Type I (PHA1).
Although this novel finding is "encouraging" and a confirmatory large randomized controlled clinical trial is likely, the study results were only partly positive; after all, the hypothesis was that stimulating the mineralocorticoid receptor would also boost the overall response rate--and it didn't happen, Dr.
Therapy insight: is there an unbalanced response of mineralocorticoid and glucocorticoid receptors in depression?
The single prolonged stress (SPS) paradigm is a validated rodent model of PTSD that replicates PTSD symptoms, which can be reversed by the anticonvulsant drug Topiramate, and also shows enhanced cortisol negative feedback and altered expression of glucocorticoid (GR) and mineralocorticoid (MR) receptors in hippocampus.
Prednisolone in children can cause growth retardation, mineralocorticoid and glucocorticoid side effects, adrenal suppression and susceptibility to infections.
Although hypertension develops in 70 to 80% of patients with Cushing syndrome, it is seen in only 15 to 20% of patients treated with high-dose synthetic corticosteroids, which have less mineralocorticoid activity than cortisol.
And, a few months later, a study demonstrated a specific mechanism for the evolution of a complex molecular system--the functional interaction of the hormone aldosterone and its partner receptor (the mineralocorticoid receptor).