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mineralocorticoid |
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mineralocorticoid [¦min·rə·lō′kȯrd·ə‚kȯid] (biochemistry) A steroid hormone secreted by the adrenal cortex that regulates mineral metabolism and, secondarily, fluid balance. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The most common type of CAH is 21-hydroxylase deficiency, within which three severity subtypes are distinguished: Saltwasters (SW), the most severe subtype, in which the enzyme deficiency causes deficiencies of both glucocorticoid (glucose-regulating) and mineralocorticoid (sodium-regulating) hormones; simple virilizers (SV), with moderate deficiencies of glucocorticoids; and the mildest subtype, non-classical (NC), late-onset CAH. Thus, one new mechanistic consideration arising from the data reported here is that Pb-induced learning impairments and/or its other central nervous system effects could arise through increased corticosterone and its influence on mineralocorticoid receptors, located primarily in the septohippocampus, and/or on glucocorticoid receptors, more widely distributed throughout the brain (Joels and de Kloet 1994). The adrenal cortex synthesizes cholesterol and secretes two major corticosteroids: the mineralocorticoids and the glucocorticoids. |
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