minichromosome


Also found in: Wikipedia.

minichromosome

[‚min·ē′krō·mə‚sōm]
(cell and molecular biology)
A eukaryotic chromosome reduced in size by deletion of a segment of deoxyribonucleic acid.
(virology)
Viral deoxyribonucleic acid combined with histone to form a chromatin-like structure.
References in periodicals archive ?
The primer ser for each gene was followed: histone deacetylase 9 (HDAC9) forward, 5'-GCAAGAGGAGACAGAGACCG-3'; HDAC9 reverse, 5' - ACTTG G C ACTTCAC AAG G CT- 3'; minichromosome maintenance deficient 3 associated protein (MCM3AP) forward, 5'-CGCTTCCTCTGGTGGTTCTT-3'; MCM3AP reverse, 5'CTGCACTGCTTGCAAAACCT-3'; GAPDH forward, 5'-TCACCCACACTGTGCCCATCTATGA-3'; GAPDH reverse, 5'-GAGGAAGAGGATGCGGCAGTGG-3'.
Markers that have been studied in the literature and that are not considered useful in the diagnosis of mesothelioma versus mesothelial hyperplasia include minichromosome maintenance 2 protein, telomerase transcriptase expression (which needs to be studied further), Ki-67, transforming growth factor, epidermal growth factor receptor, Bcl-2, and argyrophilic nucleolar organizer region.
In prostate cancer, results of a recently reported study demonstrated that binding of the vitamin D (1,25-dihydroxyvitamin D3) receptor [encoded by the vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene] to the MCM7 promoter [encoded by minichromosome maintenance complex component 7 (MCM7)] resulted in acetylation of histone H3 lysine 9 and, subsequently, enhanced transcription of miR-106b, which is located in an intron of the MCM7 gene (25).
Proteins encoded by the minichromosome maintenance (MCM) genes have also been proposed as useful markers of proliferation; with high levels of gene expression indicating poor prognosis (20).
The best studied example of colonocyte testing in feces is the minichromosome maintenance proteins (MCM).
the Company's Chief Scientific Officer, in which the author describes an emerging class of markers, the Minichromosome Maintenance protein family of DNA licensing factors (MCM-2, MCM-6, MCM-7) and Topoisomerase II alpha, that show promise for the specific detection of CIN2+ cervical conditions using simple antibody-based immunochemistry formats.
Justin Davies described a novel test that utilizes antibodies to detect minichromosome maintenance protein 2 (Mcm2) in colonocytes exfoliated onto the surface of stool.
The Minichromosome Maintenance Complex (MCM) proteins are highly expressed in malignant cells and are promising targets for anticancer drugs.
1 interacting protein 2 (PAIP2) Minichromosome maintenance complex NM_001006527.
The ProExC antibody, which targets the virally upregulated proteins minichromosome maintenance protein 2 and topoisomerase II-[alpha], can also be used as an aid in the identification of HPV-related dysplasia in the uterine cervix.
Use of linkage disequilibrium and haplotype analysis of affected Finnish families revealed a defined DNA transition (-13910T/C) proximal to the LCT gene in intron 13 of the adjacent minichromosome maintenance type 6 gene (MCM6), which is associated with verified lactase nonpersistence and reduced bone mineral density predisposing for bone fractures (1, 2).

Full browser ?