mitochondrial genome


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mitochondrial genome

[‚mīd·ə¦kän·drē·əl ′je‚nōm]
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We developed a set of 17 oligonucleotide primers to amplify the entire mitochondrial genome in overlapping segments by PCR using a single annealing temperature.
The DNA sequences traced by the researchers were chosen because of the unique way they are inherited: the Y chromosome is passed only from father to son, and the mitochondrial genome is passed from a mother to her children.
The MEDomics NextGen mitochondrial genome test can help diagnose mitochondrial disease, enabling life-saving therapy decisions and allowing for accurate family risk counseling.
Incredibly, all had the same basic mitochondrial genomes.
5-kb human mitochondrial genome there are 435 CpG sites and 4747 cytosines at non-CpG sites.
As cells contain multiple copies of the mitochondrial genome, this DNA is easier to extract from ancient remains than the DNA found in the nucleus of cells.
Using advanced techniques for fishing DNA fragments out of fossils, the team then assembled a complete mitochondrial genome for the Denisova individual.
The mitochondrial genome is a circular double-stranded 16 569-bp DNA that encodes 13 protein subunits of the enzyme complexes in the oxidative phosphorylation pathway, the 125 and 165 ribosomal RNAs, and all of the 22 transfer RNAs required for mitochondrial protein synthesis (1, 2).
Using material from a tooth, the team reconstructed the bear's mitochondrial genome, which contains genetic material passed down with few mutations through generations of females.
Mutations in the mitochondrial genome are associated with various diseases (7).

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