mitogen-activated protein kinases


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mitogen-activated protein kinases

[‚mīd·ə·jən ¦ak·tə‚vād·əd ¦prō‚tēn ′kī‚nās·əs]
(cell and molecular biology)
A large kinase network in which upstream kinases activate downstream kinases that, in response to phosphorylation, translocate to the nucleus and activate transcription factors. Abbreviated MAPKs.
References in periodicals archive ?
The mitogen-activated protein kinases (MAPK) (including extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNIKs), and p38s) plays an important regulatory role in cell proliferation, invasion, migration, metastasis, and transformation (Chang and Karin 2001); (Huang et al.
In particular, the mitogen-activated protein kinases ERK-1 and ERK-2 (extracellular signal-regulated protein kinases 1 and 2) are acutely activated by many extracellular stimuli and by oncogene products (10).
Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: a review of recent data.
Mitogen-activated protein kinases are intracellular signaling molecules that include the extracellular signal-regulated kinases (ERK-1 and ERK-2).
The mitogen-activated protein kinases (MAPKs) are a group of signaling molecules that play a critical role in the regulation of cell growth and differentiation, as well as in the control of cellular responses to cytokines and stresses.
After incubation with 20 [micro]M TCHQ for 1 hr, all mitogen-activated protein kinases (MAPKs) examined [i.
With regard to the regulation of TNF-[alpha], mitogen-activated protein kinases (MAPKs) family including p38 kinase, c-jun N-terminal kinase (JNK) and extracellular signal regulated kinase (ERK) are important mediators.
This is followed by activation of protein kinase C, mitogen-activated protein kinases (MAPKs) and transcription factor nuclear factor-kappa B (NF-[kappa]B) and releasing of inflammatory cytokines (Kalesnikoff and Galli 2008).
Increasing evidences demonstrate that oxidants and antioxidants influence important signal cascades such as mitogen-activated protein kinases (MAPK), which control proliferation and apoptosis and thus tissue regeneration.
The downstream components; mitogen-activated protein kinases, Hsp90 and calmodulins are involved in the activation of Heat-shock transcription factors (Hsf).
Beyond the multiple cell types (inflammatory cells, epithelial cells, fibrogenic effector cells, endothelial cells, and others) involved in the fibrogenic response, three cellular signal transduction pathways play leading roles in the process of fibrosis: transforming growth factor-beta (TGF-[sz]), mitogen-activated protein kinases (MAPKs) and integrins.
The mitogen-activated protein kinases (MAPKs), the family of the serine-threonine protein kinases that transduce signals from the cell membrane to the nucleus, include extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs) and p38 and, in particular, participate in oxidative stress-induced cell apoptosis and proliferation [14].
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