modifier gene


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Related to modifier gene: recessive epistasis, epistatic

modifier gene

[′mäd·ə‚fī·ər ‚jēn]
(genetics)
A gene that alters the phenotypic expression of a nonallelic gene.
References in periodicals archive ?
Therefore, we attempted to understand whether human BOP gene might be a modifier gene for HCMP In this purpose, we analyzed all coding regions of human BOP gene both in the patients diagnosed with HCMP and in the healthy controls.
Thus, nuclear modifier genes or other modifier factors may modulate the phenotypic manifestation of the 12S rRNA gene mutations by interacting with the gene either suppressing/enhancing the effect of the mutation (75,98).
In order to identify candidate modifier genes, the investigators performed a whole genome mutagenesis screen.
A key aspect of this work was learning how to ask questions of massive data sets to glean information about the identities of heritable modifier genes," Sutcliffe said.
We also have planned studies to search for modifier genes that modulate the severity of CF lung disease and may have an impact on the severity of other chronic bronchitic airway diseases in humans.
3) research on modifier genes and environmental influences in animal models;
I'm sure we'll learn that there are other, modifier genes involved," he adds.
Confounding the problem further are environmental influences, originating either in the chromosomal environment from modifier genes, or in the extra-chromosomal environmental from intrauterine or postnatal influences.
The lab has studied the molecular basis of von Willebrand disease (VWD), the most common inherited bleeding disorder, and identified modifier genes that control the severity of VWD.