director, Medicinal & Synthetic Chemistry, SRI Biosciences, has been doing for years: looking at a little-appreciated molecular machine
called the spliceosome that is now gaining more recognition in scientific circles.
Five work packages will investigate cohesin s molecular behaviour during its life-cycle on chromosomes, including the ATP binding and hydrolysis-dependent conformational changes that make this molecular machine
Their data suggest that Taranis and Cyclin A create a molecular machine
that inactivates Cdk1, whose normal function is to suppress sleep and promote wakefulness.
A new field called nano-medicine is emerging which is the science and technology of diagnosing, treating and preventing disease and traumatic injury, relieving pain and preserving human health using nanocstructured materials and eventually complex molecular machine
systems and nano-robots".
Focusing on the work of Gary Lynch and his research team at the University of California, this book shows how cutting-edge science has revealed the inner workings of the molecular machine
that manufactures our memories, and the discovery of a new class of drugs that not only enhance brain function but offer tantalizing possibilities for curing many neurological diseases.
His research interests include: nanomedicine, medical nanorobotics design, molecular machine
systems, diamondoid mechanosynthesis (theory and experimental pathways), molecular assemblers and nanofactories, and self-replication in machine and factory systems.
They're working on a transition metal-based chemical catalyst, a sort of reusable molecular machine
that will convert glucose or other carbohydrates into usable starting points for manufacturing chemicals and plastics.
Jacobson, Associate Professor, Massachusetts Institute of Technology; co-PI of the Center for Bits and Atoms; leader of the Molecular Machine
Group; co-founder of Gen9, E Ink, Kovio; and recipient of the 2000 Gutenberg Prize
5) Drexler, who is currently an advisor to Nanorex (a company developing software for the design and simulation of molecular machine
systems), often delivered visionary lectures describing a "diamond spacecraft" with a higher strength-to-weight ratio than the space shuttle.
The most extraordinary of these molecular factories is the ribosome, a molecular machine
found in all living cells that assembles amino acids from transfer RNA (tRNA) building blocks into a peptide chain with an order defined by the sequence of the messenger RNA (mRNA) strand that it moves along.
Defective proteins are sent to the proteasome, a molecular machine
(found in all of our cells) that eliminates defective proteins by recycling them back to their building blocks.
The new structure shows that, like a wrench in the works, halofuginone jams the gears of a molecular machine
that carries out "aminoacylation," a crucial biological process that allows organisms to synthesize the proteins they need to live.