molecular mimicry


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molecular mimicry

[mə′lek·yə·lər ′mim·i‚krē]
(immunology)
The sharing, by two organisms closely related ecologically but not phylogenetically, of common macromolecular structures that are not attributable to evolutionary conservation of these structures.
References in periodicals archive ?
A virus-induced molecular mimicry model of multiple sclerosis.
The use of bacterial antigen EPD and LDA immunotherapy for the treatment of rheumatoid arthritis and reactive arthritis: the role of molecular mimicry.
A primary objective in the Company's vaccine design program is to impair the molecular mimicry between gp41 and the IL-2 cytokine (Interleukin-2) of the infected host.
Potential mechanisms include immune complex disease, molecular mimicry, and adjuvant rather than antigen reactions.
One infection-based theory of autoimmunity, known as molecular mimicry, begins with the observation that some molecules of microorganisms resemble those of the host they infect.
The EPO-like peptides represent a major milestone in molecular mimicry and are "enough to reinstate one's belief in Santa Claus," James A.
Based on this understanding of molecular mimicry, Mymetics has been able to engineer gp41 proteins capable of eliciting neutralizing antibodies against primary HIV-1 strains and has also designed specific therapeutic molecules which have the potential to prevent and/or delay the disease.
Molecular mimicry may indeed allow a natural infection to trigger an autoimmune disease, as when Lyme disease leads to chronic arthritis.
Mymetics is testing a novel class of anti-retroviral agents designed to disrupt molecular mimicry, an inter-reaction between a retrovirus and host cells discovered by the Company which contributes to disease progression.
The Mymetics peptides were developed to disrupt a phenomenon Mymetics discovered called molecular mimicry, which describes an inter-reaction between the virus and the host cell that contributes to disease replication.
In the field of HIV, Mymetics' innovative products are based on the discovery of a precise and functional tridimensional molecular mimicry between a conserved part of GP41, the HIV transmembrane protein, in a trimeric form and interleukine-2, the immune system's conductor protein.
Hippocampe believes to have made a major discovery with a new and precise molecular mimicry between a conserved part of GP41 in a trimeric form, a major HIV transmembrane protein, and Interleukine 2 or IL-2, the immune system's "conductor" protein.
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