molecular mimicry


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molecular mimicry

[mə′lek·yə·lər ′mim·i‚krē]
(immunology)
The sharing, by two organisms closely related ecologically but not phylogenetically, of common macromolecular structures that are not attributable to evolutionary conservation of these structures.
References in periodicals archive ?
Molecular mimicry and autoimmune liver disease: virtuous intentions, malign consequences.
Our results supported the molecular mimicry hypothesis and might conclude that CagA antigen shared similar antigenic epitopes with GPIIb/IIIa instead of GPIb.
1994) Molecular mimicry between GQ1b ganglioside and lipopolysaccharide of Campylobacter jejuni isolated from patients with Fisher's syndrome.
In conclusion, the chronic inflammation production in BD may be caused by result of molecular mimicry.
Antecedent infections in Fisher syndrome: a common pathogenesis of molecular mimicry.
Molecular mimicry is in some ways an 'allergy' to an infection (Mills 1991).
One theory is that PANDAS arises because of molecular mimicry, with antibodies intended to attack-group A strep targeting brain proteins instead.
Their topics include cellular inorganic chemistry concepts and examples, essential and toxic metal transport in the liver, the transport and biological impact of manganese, metallothionein and metal homeostasis, the regulatory and signaling functions of zinc ions in human cellular physiology, ionic and molecular mimicry and the transport of metals, heavy metal transport and detoxification in crustacean gastrointestinal and renal epithelial cells, metals and cell adhesion molecules, and metal influences on immune function.
30) These observations support intra-molecular antigenic spread and suggest that T-cell anti-EBV immune responses in MS are enhanced and may be driving MS disease activity via molecular mimicry.
Molecular mimicry has been proposed for the development of catastrophic APS following infections.
There is recent evidence that interaction between LAMP-2 and fimbriated bacteria produces a human-like ANCA-associated vasculitis in animals through molecular mimicry.
For this model to be relevant to multisystem autoimmune diseases would require expansion of the immune response to other organs, though mechanisms, such as molecular mimicry or, in the case of an infectious trigger, selective binding to common or similar ligands in multiple organs in which neoantigens or modified antigens are generated.
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