A virus-induced molecular mimicry
model of multiple sclerosis.
The use of bacterial antigen EPD and LDA immunotherapy for the treatment of rheumatoid arthritis and reactive arthritis: the role of molecular mimicry
A primary objective in the Company's vaccine design program is to impair the molecular mimicry
between gp41 and the IL-2 cytokine (Interleukin-2) of the infected host.
Potential mechanisms include immune complex disease, molecular mimicry
, and adjuvant rather than antigen reactions.
One infection-based theory of autoimmunity, known as molecular mimicry
, begins with the observation that some molecules of microorganisms resemble those of the host they infect.
The EPO-like peptides represent a major milestone in molecular mimicry
and are "enough to reinstate one's belief in Santa Claus," James A.
Based on this understanding of molecular mimicry
, Mymetics has been able to engineer gp41 proteins capable of eliciting neutralizing antibodies against primary HIV-1 strains and has also designed specific therapeutic molecules which have the potential to prevent and/or delay the disease.
may indeed allow a natural infection to trigger an autoimmune disease, as when Lyme disease leads to chronic arthritis.
Mymetics is testing a novel class of anti-retroviral agents designed to disrupt molecular mimicry
, an inter-reaction between a retrovirus and host cells discovered by the Company which contributes to disease progression.
The Mymetics peptides were developed to disrupt a phenomenon Mymetics discovered called molecular mimicry
, which describes an inter-reaction between the virus and the host cell that contributes to disease replication.
In the field of HIV, Mymetics' innovative products are based on the discovery of a precise and functional tridimensional molecular mimicry
between a conserved part of GP41, the HIV transmembrane protein, in a trimeric form and interleukine-2, the immune system's conductor protein.
Hippocampe believes to have made a major discovery with a new and precise molecular mimicry
between a conserved part of GP41 in a trimeric form, a major HIV transmembrane protein, and Interleukine 2 or IL-2, the immune system's "conductor" protein.