molecular recognition


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Molecular recognition

The ability of biological and chemical systems to distinguish between molecules and regulate behavior accordingly. How molecules fit together is fundamental in disciplines such as biochemistry, medicinal chemistry, materials science, and separation science. A good deal of effort has been expended in trying to evaluate the underlying inter-molecular forces. The weak forces that act over short distances (hydrogen bonds, van der Waals interactions, and aryl stacking) provide most of the selectivity observed in biological chemistry and permit molecular recognition. The recognition event initiates behavior such as replication in nucleic acids, immune response in antibodies, signal transduction in receptors, and regulation in enzymes. Most studies of recognition in organic chemistry have been inspired by these biological phenomena. It has been the task of bioorganic chemistry to develop systems capable of such complex behavior with molecules that are comprehensible and manageable in size, that is, with model systems. See Antibody, Chemoreception, Enzyme, Nucleic acid, Synaptic transmission

molecular recognition

[mə¦lek·yə·lər ‚rek·ig′nish·ən]
(cell and molecular biology)
The ability of biological and chemical systems to distinguish between molecules and regulate behavior accordingly.
(chemistry)
The (molecular) storage and the (supramolecular) retrieval and processing of molecular structural information and interactions.
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He has been a leader in computational studies of organic and enzymatic reactions in solution, molecular recognition, protein-ligand binding, and molecular properties.
Our objective is to design a zeolite synthesis methodology that creates pores and cavities in the resulting zeolite that approach a molecular recognition pattern to catalyze the desired reaction.
Molecular imprinting is a tool for synthesizing tailor-designed molecular recognition sites in polymers structured at micrometer and nanometer scales.
Our biosensor test uses a new molecular recognition tool that works like a lock that only fits one key; it picks out the ball-shaped amyloid clusters without detecting the individual amyloids.
In their article entitled "The case for intrinsically disordered proteins playing contributory roles in molecular recognition without a stable 3D structure" (http://f1000.
The idea is to take something we normally think of as plastic, and enable it to adopt structures that are more complex and capable of higher function, such as molecular recognition, which is what proteins do really well," said Zuckermann.
Introductory chapters review how peptides can characterize proteins and the molecular recognition events in which they are involved.
Siva's research investigates the molecular and supramolecular assembly characteristics of systems to gain a deeper understanding of the interplay between molecular structure, assembly, dynamics and the role of external interactions critical for molecular recognition events in light-initiated reactions.
This method is based on the template synthesis of SIP microrods, where we use poly(3,4-ethylenedioxythiophene) (PEDOT) as the molecular recognition matrix, which is formed within the pores of a track-etched polycarbonate membrane (PCM), modified with a target protein--fluorescently labelled avidin (Av-FITC).
Warner directs a large research group working on a diverse set of projects involving green chemistry using principles of crystal engineering, molecular recognition, and self assembly.
Jonathan Javitch, senior author of the Molecular Cell study and contributing author to the Nature Neuroscience study, and professor of Psychiatry and Pharmacology in the Center for Molecular Recognition at Columbia University Medical Center, stabilized different structural states of the neurotransmitter-sodium-symporter molecule that relate to steps in its function.
These weak interactions are very difficult to model and it would appear as if a very high level of theory is needed to describe molecular recognition to that level.

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