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monoclonal antibody

   Also found in: Dictionary/thesaurus, Medical, Financial, Acronyms, Wikipedia 0.02 sec.
monoclonal antibody, an antibody that is mass produced in the laboratory from a single clone and that recognizes only one antigen. Monoclonal antibodies are typically made by fusing a normally short-lived, antibody-producing B cell (see immunity immunity, ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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) to a fast-growing cell, such as a cancer cell (sometimes referred to as an "immortal" cell). The resulting hybrid cell, or hybridoma, multiplies rapidly, creating a clone that produces large quantities of the antibody.

Monoclonal antibodies engendered much excitement in the medical world and in the financial world in the 1980s, especially as potential cures for cancer. They have been used in laboratory research and in medical tests since the mid-1970s, but their effectiveness in disease treatment has been limited. By the mid-1990s, however, some of the technical problems had been overcome. Experimental cancer therapies have used drugs, radioactive materials, or immune killer cells attached to monoclonal antibodies that, when injected into patients, home in on antigens that grow only on the surface of cancer cells.


monoclonal antibody
an antibody, produced by a single clone of cells grown in culture, that is both pure and specific and is capable of proliferating indefinitely to produce unlimited quantities of identical antibodies: used in diagnosis, therapy, and biotechnology

monoclonal antibody [¦män·ə¦klō·nəl ′ant·i‚bäd·ē]
(immunology)
A highly specific antibody produced by hybridoma cells; the antibody binds with a single antigenic determinant.


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Gaithersburg, MD) has patented a method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal antibody under conditions permitting the formation of a complex between the antibody and the reactant.
The first-ever monoclonal antibody obtained from transgenic plants for the purpose of purifying a human vaccine was registered in Cuba by the State Center for the Control of Medication Quality (CECMED), a regulatory arm of Cuba's Ministry of Public Health.
The Toxin B monoclonal antibody we have identified is the first monoclonal antibody from any source capable of neutralizing the toxin.
 
 
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Monoclonal Anti-TNF: A Randomized Controlled Sepsis
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monoclonal antibody immobilisation of erythrocyte antigen
monoclonal antibody immobilisation of granulocyte antigens
Monoclonal Antibody Immobilization of Leukocyte Antigens
Monoclonal Antibody Immobilization of Platelet Antigen
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Monoclonal Antibody to Angiotensin II
Monoclonal Antibody-Based Immunoassay
Monoclonal B Cells in Peripheral Blood
Monoclonal B-Cell Lymphocytosis
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Monoclonal Enzyme Immunoassay
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Monoclonal Gammopathies of Unknown Significance
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