monoclonal antibody

Also found in: Dictionary, Thesaurus, Medical, Financial, Acronyms, Wikipedia.

monoclonal antibody,

an antibody that is mass produced in the laboratory from a single clone and that recognizes only one antigen. Monoclonal antibodies are typically made by fusing a normally short-lived, antibody-producing B cell (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
..... Click the link for more information.
) to a fast-growing cell, such as a cancer cell (sometimes referred to as an "immortal" cell). The resulting hybrid cell, or hybridoma, multiplies rapidly, creating a clone that produces large quantities of the antibody.

Monoclonal antibodies engendered much excitement in the medical world and in the financial world in the 1980s, especially as potential cures for cancer. They have been used in laboratory research and in medical tests since the mid-1970s, but their effectiveness in disease treatment was limited especially by the tendency of the early monoclonal antibodies to provoke an immune response against them because of the use of mouse cells in creating the hybridoma. This problem has been overcome through the use of recombinant DNA to produce chimeric and humanized monoclonal antibodies and of transgenic mice and other techniques to produce human antibodies. Monoclonal antibody therapies have been developed to treat transplant rejection, some autoimmune diseases, and some types of lymphoma, leukemia, and breast and other cancers. These therapies use monoclonal antibodies to home in on specific antigens found on the surface of targeted cells to deliver radioactive materials, drugs or inactive drug precursors (subsequent converted to a drug by an enzyme), tumor-suppressing genes, or substances that suppress or inhibit signaling molecules involved in disease processes.


See study by L. V. Marks (2015).

monoclonal antibody

[¦män·ə¦klō·nəl ′ant·i‚bäd·ē]
A highly specific antibody produced by hybridoma cells; the antibody binds with a single antigenic determinant.

monoclonal antibody

an antibody, produced by a single clone of cells grown in culture, that is both pure and specific and is capable of proliferating indefinitely to produce unlimited quantities of identical antibodies: used in diagnosis, therapy, and biotechnology
References in periodicals archive ?
Most important, he says, is that because the monoclonal antibody was given to the patients for only about 2 weeks, they weren't exposed to the risks of long-term immune suppression.
Our US partner is providing us with a monoclonal antibody for a first phase proof of principle project.
This report contains over 1,000 links to online copies of actual cancer monoclonal antibody deals and where available, contract documents as submitted to the Securities Exchange Commission by companies and their partners.
Chapter 3 - Average financial deal terms for cancer monoclonal antibody partnering
Research and Development of Chinese Monoclonal Antibody Market
Development of Global Monoclonal Antibody Industry 2.
Diya Lahiri, pharmaceutical industry analyst, said: "The world market for monoclonal antibody treatments will benefit from the entry of new products this decade.
The newly approved monoclonal antibody, caled OKT3, attacks T cells, a subset of which can cause acute rejection of the kidney.
This report explains what monoclonal antibodies are, and why large pharmaceutical companies are investing so heavily both in developing such drugs internally and acquiring monoclonal antibody candidates from others.
All 10 mice given the human monoclonal antibody survived a high dose of bacterium.
Trends in cancer monoclonal antibody partnering deals Disclosed headlines, upfronts, milestones and royalties by stage of development Cancer monoclonal antibody partnering contract documents Top cancer monoclonal antibody deals by value The Cancer Monoclonal Antibody Partnering Agreements report provides an understanding and access to the cancer monoclonal antibody partnering deals and agreements entered into by the worlds leading healthcare companies.
Reportlinker Adds Monoclonal Antibody Therapeutics 2009-2024

Full browser ?