monocyte


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Related to monocyte: Lymphocytes, basophil, eosinophil

monocyte

[′män·ə‚sīt]
(histology)
A large (about 12 micrometers), agranular leukocyte with a relatively small, eccentric, oval or kidney-shaped nucleus.
References in periodicals archive ?
For analysis of the pyrogenic reactions, the PyroDetect System (EMD Millipore, Darmstadt, Germany), which is based on MAT, was used to assess pyrogens known to interact with different receptors on and in monocytes.
The aim of this study is to investigate the intracellular ionic fluctuations in human monocytes after exposure to bioactive glass particles.
The ARIC Carotid MRI study, which enrolled participants from the ARIC cohort, was designed to further improve our understanding of cellular factors by examining the association of markers of platelet and monocyte activation and cellular aggregation with atherosclerotic plaque characteristics and early pathologic changes in the carotid arterial wall.
Monocytes are large white blood cells that, during an inflammatory response, are recruited to the site of infection, often within ECM rich tissues, and undergo differentiation into macrophages.
Clint Robbins, lead author on the study and an Assistant Professor in U of T's Departments of Laboratory Medicine and Pathobiology, and Immunology, said that until now, the thinking was that inflammatory macrophages arise mainly from the recruitment of their precursors - monocytes - from the bloodstream.
Recently, we showed that TF mRNA expression was increased in monocyte cells isolated from hypertensives with carotid atherosclerosis (22).
Nonadherent cells were then removed, and adherent monocytes were washed twice with Seligman's buffered saline solution (SBSS) and supplied with fresh complete M-CSF-free leukocyte culture medium.
Flow cytometric analysis of the original diagnostic BM revealed 38% of cells within the lymphocyte region, 40% within the monocyte region, and 22% within the granulocyte region.
With these new findings, we have demonstrated broad-based efficacy of targeting monocyte CCR2 as an anti-inflammatory strategy in cardiovascular disease, cancer and transplant rejection," said Matthias Nahrendorf, M.

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