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monogenic |
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monogenic [‚män·ə′jen·ik] (genetics) Relating to or controlled by one gene. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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These include the discovery of a monogenic form of vascular dementia, CADASIL, and identification of the causative gene as Notch 3. Yair Reisner and his research team from the Weizmann Institute of Science published an article in the December 12, 2006 issue of PNAS (Proceedings of the National Academy of Sciences) entitled "Correcting Monogenic Diseases by Fetal Spleen Transplantation: Hemophilia as a Proof of Concept". Because of the complex interplay between the pharmacologic effects of drugs and disease pathophysiology, inherited differences in drug responses are most likely polygenic rather than monogenic in nature (Evans and McLeod 2003). |
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