monogenic


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Related to monogenic: monogenic disease

monogenic

[‚män·ə′jen·ik]
(genetics)
Relating to or controlled by one gene.
References in periodicals archive ?
Imperial College London Diabetes Centre (ICLDC) has the first clinic dedicated to the genetics of diabetes and endocrine disorders in the GCC region, which is currently caring for 165 individuals with diverse types of monogenic diabetes and genetic endocrine disorders.
In essence, the methods and illustrations described in this communication tend to simplify the observation of genotype and phenotype probabilities for monogenic Mendelian inheritance.
The genetic basis of monogenic autoinflammatory diseases and the importance of genetic diagnosis
Therefore, the possibility of monogenic inheritance should not be discarded based only on the analysis of the results for the [F.
According to the results of the chi-square test with a 1% level of significance, it was possible to reject the hypothesis of monogenic inheritance, as results indicated that more genes are involved in the control of resistance.
There is substantial clinical variability between patients with GoF STAT3 mutations and also overlap in phenotype with other monogenic autoimmune disorders such as immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome (MIM: 304790) resulting from hemizygous loss-of-function forkhead box P3 (FOXP3) mutations, and also early-onset polygenic autoimmune disease.
PGD is available for a large number of monogenic disorders such as single gene disorders (autosomal recessive, autosomal dominant or X-linked) or chromosomal structural aberrations (such as a balanced translocation).
Of course, for some markers (notably those which are directly causal of monogenic traits, such as, say, a mutation for sickle cell anemia), as opposed to ones which are just linked and/or are part of complex polygenic traits, this isn't the case; a definite phenotype or condition can be confidently reported.
Among stereotypical recurrent fevers, irregular episodes likely indicate a monogenic fever syndrome, while more predictable episodes could be cyclic neutropenia or PFAPA.
Thalassemia is one of the most prevalent monogenic disorders which appears due to the non- or reduced synthesis in one or more globin chains.
To reduce the burden of highly prevalent monogenic disorders, it is essential that disease progression be halted at the carrier stage.
Cleft lip and/or palate with monogenic autosomal recessive transmission in Pyrenees shepherd dogs.