monokine


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monokine

[′män·ə‚kīn]
(biochemistry)
A cytokine released from macrophages.
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Caption: Figure 4: Concentrations of interleukin- (IL-) 1[beta], IL-6, tumor necrosis factor- (TNF-) [alpha], interferon- (IFN-) [gamma], monokine induced by IFN-[gamma] (MIG), and IFN-[gamma]-induced protein- (IP-) 10 in untreated control (UT), experimental dry eye (EDE), balanced salt solution (BSS), and 0.
There are several different types of cytokines such as monokines (cytokines produced by monocytes and macrophages), lymphokines (cytokines produced by lymphocytes), inflammatory peptides (cytokines produced by neutrophils), and vasoactive amines (cytokines produced by platelets and mast cells).
Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression.
Monokine expression in Langerhans' cell histiocytosis and sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) [see comments].
Age-related changes in monokine production are not well delineated at this time; however, recent work comparing activated monocytes from older and young adults reveals diminished interleukin 1 (IL1) production, impairment of the oxidative burst, and a loss of tumoricidal capacity in monocytes from older adults.
Chemokines: CXCL8/IL-8, monokine induced by interferon-[gamma] (IFN- [gamma]) (CXCL9/MIG), IFN-[gamma]--inducible protein-10 (CXCL10/IP-10), monocyte chemoattractant protein--1 (CCL2/MCP-1), and regulated upon activation normal T cell--expressed and secreted (CCL5/RANTES).
Itoh Y, Okanoue T, Sakamoto S, Nishioji K, Yasui K, Sakamoto M, Kashima K (1995) Monokine production by peripheral whole blood in chronic hepatitis C patients treated with interferon.
Monokine induced by interferon gamma and IFN-gamma response to a fusion protein of Mycobacterium tuberculosis ESAT-6 and CFP-10 in Brazilian tuberculosis patients.
To clarify the immune responses mediated by ficolins in the placenta during preeclamptic pregnancy, we found that chemokines/cytokines involved in innate immunity, including monocyte chemoattractant proteins 1/2/3 (MCP1/2/3), monokine induced by gamma-interferon (MIG), macrophage inflammatory proteins 1[delta]/3[alpha] (MIP1[delta]/3[alpha]), tumor necrosis factor [alpha] (TNF[alpha]) and thymus expressed chemokine (TECK) were activated, whereas interferon/cytokines involved in adaptive immunity, including interferon [gamma] (IFN[gamma]), interleukin 13/4/5 (IL13/4/5), transforming growth factor [beta]1/[beta]3 (TGF[beta]1/[beta]3) and TNF[beta], were suppressed in preeclamptic placenta (n = 10 vs 10; Fig.
Lemaire 1(1991) Selective differences in macrophage populations and monokine production in resolving pulmonary granuloma and fibrosis.
Serum concentrations of interleukin-8 (IL-8), monocyte chemoattractant protein (MCP) 1 (MCP-1) and monokine induced by IFN-[gamma] (MIG/CXCL9) are also elevated in both samples.
3] Nonstandard abbreviations: VLBW, very low birth weight; DIC, disseminated intravascular coagulation; IL, interleukin; NEC, necrotizing enterocolitis; IP-10, interferon-[gamma]-inducible protein-10; MIG, monokine induced by interferon-7; MCP-1, monocyte chemoattractant protein-1; RANTES, regulated upon activation normal T cell expressed and secreted; TNF-[alpha], tumor necrosis factor-[alpha]; CRP, C-reactive protein; and ELR, glutamic acid-leucine-arginine.