morphogen


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morphogen

[′mȯr·fə·jən]
(biochemistry)
Any compound that exerts a morphogenetic effect at low concentrations.
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Kealey, "The role of IGF-I in human skin and its appendages: morphogen as well as mitogen?
MPs generated from the activated T -lymphocyte, harboring the morphogen Sonic Hedgehog, regulate angiogenesis through both direct and indirect mechanisms (52).
The morphogen theory posits that proteins controlling traits are arranged as gradients, with different amounts of proteins activating genes to create specified physical features.
compile 19 chapters that explore how morphogen gradients are generated and interpreted during embryonic development, addressing which mechanisms ensure the formation of stable and reliable morphogen concentration, how cells within a field assess their position by reading the local concentration, and how graded responses of cells are transformed into differential gene expression to control the fate and behavior of cells.
It is likely that all-trans-retinoic acid (produced by cells from vitamin A) is a morphogen and excess, or indeed treatment with a variety of retinoids, can potentially have disastrous effects on the developing fetus.
First, 5HT is a morphogen in the developing mammalian central nervous system; perturbations of this system lead to errors in the architectural assembly of the brain (Hamon et al.
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning.
Several private companies (such as MorphoGen, NeuralStem, Osiris Therapeutics, StemSource, ViaCell) are working on additional therapeutic uses of adult stem cells.
Moreover, the researchers found that a morphogen called Wingless is almost always in parts of the embryo where there are argosomes.
Cells at different distances from the focus would experience different morphogen concentrations at the time of pattern determination, leading them later to produce different pigments.
The truly amazing thing about the morphogen genes, says developmental biologist Cliff Tabin, is that they are active in so many parts of the embryo.
The claims of this patent recite a method for the use of a particular OP/BMP morphogen to promote dendrite outgrowth by a neuron.