morphogen


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morphogen

[′mȯr·fə·jən]
(biochemistry)
Any compound that exerts a morphogenetic effect at low concentrations.
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MPs generated from the activated T -lymphocyte, harboring the morphogen Sonic Hedgehog, regulate angiogenesis through both direct and indirect mechanisms (52).
The morphogen theory posits that proteins controlling traits are arranged as gradients, with different amounts of proteins activating genes to create specified physical features.
Bicoid is a morphogen protein critical to fruit fly embryos in forming the head and thorax.
compile 19 chapters that explore how morphogen gradients are generated and interpreted during embryonic development, addressing which mechanisms ensure the formation of stable and reliable morphogen concentration, how cells within a field assess their position by reading the local concentration, and how graded responses of cells are transformed into differential gene expression to control the fate and behavior of cells.
The researchers have thought that these so-called morphogens create chemical maps by simply diffusing through an embryo.
Equally amazing, says Tabin, is that the morphogen genes are used to trigger embryonic development in many different species.
patent 6,936,582, entitled "Synergistic Effects of OP/BMP Morphogens and GDNF/NGF Neurotrophic Factors.
My goal is to consolidate a world-class morphogen signal transduction laboratory, deciphering fundamental biological insights.
He was Vice President of Process and Product Development, at Morphogen Pharmaceuticals Inc.
Even though the current view is that a morphogen gradient drives the spatial arrangement of Bra expression, the precise mechanisms controlling timing and coordination of cells remain to be elucidated.
Thus, Sundaresan began searching for a substance in Arabadopsis that might be acting as a morphogen.
5 billion has been invested, the opportunity for additional investment has been challenged," says Patrick Driscoll, President of MedMarket Diligence, "yet new financing has nonetheless happened for companies like Geron, Osiris Therapeutics, BresaGen, ViaCell, NeuralStem, NeuroNova, Aastrom Biosciences, Layton Bioscience, MorphoGen Pharmaceuticals and StemCells.