disorder

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Related to multifactorial disorder: polygenic disease, inherited diseases

disorder

[dis′ȯrd·ər]
(crystallography)
Departures from regularity in the occupation of lattice sites in a crystal containing more than one element.
References in periodicals archive ?
All these papers assume that the genetic epidemiology implies that genetic tests carry very strong information about risk, true of some single-gene disorders but unlikely to be so true of multifactorial disorders.
As the name suggests, multifactorial disorders involve not only one's genetic inheritance, they also involve environmental factors such as parental diet, health, and behavior and overall climate of the fertilization event.
Genetic tests offered for health-related traits can be broadly divided into two main classes: tests for monogenic and for complex multifactorial disorders.
In the case of multifactorial disorders, where multiple biochemical and physiologic pathways may be involved, the need for "carefully generated distinct phenotypes" becomes even more critical.
The authors also record a large number of diagnoses of genetic, cytogenetic and multifactorial disorders in persons of Indian ancestry.
Chromosomal abnormalities cause some miscarriages but more likely explanations are Mendelian disorders (single-gene anomalies) or polygenic multifactorial disorders, he said.
From a genetic perspective, this is currently only possible for monogenic/mendelian disorders (such as cystic fibrosis, Duchenne muscular dystrophy or osteogenesis imperfecta) but not for the more common so-called multifactorial disorders such as diabetes, obesity and ischaemic heart disease, which arise from variants in several genes in a given individual and their interaction with the environment.

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