multiple isomorphous replacement technique

multiple isomorphous replacement technique

[‚məl·tə·pəl ‚ī·sə‚mȯr·fəs ri′plās·mənt tek‚nēk]
(crystallography)
A technique for overcoming the phase problem by growing crystals in three different isomorphic chemical forms and comparing x-ray diffraction data obtained from all three. Abbreviated MIR technique.
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The three-dimensional structure of the sigma-class glutathione S-transferase in complex with the product 1-(S-glutathionyl)-2,4-dinitrobenzene zene was solved by multiple isomorphous replacement techniques to a resolution of 2.

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