muscarine

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muscarine

[′məs·kə‚rēn]
(organic chemistry)
C8H19NO3 A quaternary ammonium compound, the toxic ingredient of certain mushrooms, as Amanita muscaria. Also known as hydroxycholine.
References in periodicals archive ?
As a muscarinic antagonist (blocker), trospium chloride could potentially inhibit xanomeline's binding to peripheral receptors, and therefore improve xanomeline's safety profile.
Autoantibodies to beta adrenergic receptors and/or muscarinic receptors have also been linked to some cases of DCM, Chagas, post MI, ischemic HF, atrial fibrillation, ventricular tachycardia, and DAN.
interaction with muscarinic antagonists in isolated human bronchi
The muscarinic receptor is a kind of GPCR, while [beta]-arrestin-1 is known as a terminator of GPCR signaling.
Ten nM thapsigargin (a SERCA inhibitor), 1 [micro]M atropine (a muscarinic receptor blocker) and 100 [micro]M L-NAME (a NO synthase inhibitor) and 500 uM DECC were used to investigate the mechanisms of DECC action.
Evidence from an animal model has shown that chronic administration of antimuscarinic agents (oxybutynin or fesoterodine) leads to loss of muscarinic receptor efficiency and induces a shift from muscarinic to purinergic transmission.
An important role of parasympathetic cholinergic neurons and postsynaptic muscarinic acetylcholine receptors in the contraction of gastric smooth muscle has been provided in functional studies (Makhlouf and Murthy, 2006).
Theravance's key programs include: Relovair(TM), LAMA/LABA ('719/vilanterol (VI)) and MABA (Bifunctional Muscarinic Antagonist-Beta2 Agonist), each partnered with GlaxoSmithKline plc, and its oral Peripheral Mu Opioid Receptor Antagonist (PuMA) program.
Anticholinergic agents that show antagonistic effects mainly on muscarinic receptor are thought to be effective in treating OAB.
Muscarinic cholinoceptors in the ventromedial hypothalamic nucleus facilitate tail heat loss during physical exercise.
The acetylcholine receptors are divided into muscarinic and nicotinic subtypes.
SANTIAGO, CHILE -- Treatment with scopolamine hydrobromide blocks muscarinic cholinergic receptors and produces a rapid, robust antidepressant response in depressed patients with unipolar or bipolar depression, Maura L.